Evidence map›Paper›PMID 29296821›Full record

ArticleBlood advances2017

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways.

Sheryl M Gough, Liat Goldberg, Marbin Pineda, Robert L Walker, Yuelin J Zhu, Sven Bilke, Yang Jo Chung, Joseph Dufraine, Subhadip Kundu, Elad Jacoby and 5 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Structure, function, and pathology of PHF23.Frontiers in cell and developmental biology · 2025
    Review
  4. Review
  5. Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Sheryl M GoughGenetics Branch and.
Liat GoldbergGenetics Branch and.
Marbin PinedaGenetics Branch and.
Robert L WalkerGenetics Branch and.
Yuelin J ZhuGenetics Branch and.
Sven BilkeGenetics Branch and.
Yang Jo ChungGenetics Branch and.
Joseph DufraineGenetics Branch and.
Subhadip KunduGenetics Branch and.
Elad JacobyPediatric Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Terry J FryPediatric Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Susanna FischerLeukemia Biology Group, Children's Cancer Research Institute, Vienna, Austria; and.
Renate Panzer-GrümayerLeukemia Biology Group, Children's Cancer Research Institute, Vienna, Austria; and.
Paul S MeltzerGenetics Branch and.
Peter D AplanGenetics Branch and.
Institut thématique Génétique, génomique et bioinformatique · FRSt Anna Children's Hospital · ATCenter for Cancer Research · USNational Cancer Institute · US

Funding

Activation of Proto-Oncogenes by Chromosomal TranslocationZIASC010378 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.4M
Optimizing the graft versus leukemia effect for pediatric ALLZIABC011295 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FRY, TERRY · 2010 to 2018
$4.8M
Activation of Proto-Oncogenes--Chromosomal TranslocationZ01SC010378 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER D · 2001 to 2008
$1.5M
Pre-clinical Studies of Therapy for Myelodysplastic SyndromeZ01BC010983 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2008 to 2008
$344k
Intramural NIH HHS Z01 BC010983Intramural NIH HHS Z01 SC010378Intramural NIH HHS ZIA SC010378
6 · The paper itself

Abstract

B-1 and B-2 lymphocytes are derived from distinct developmental pathways and represent layered arms of the innate and adaptive immune systems, respectively. In contrast to a majority of murine B-cell malignancies, which stain positive with the B220 antibody, we discovered a novel form of B-cell leukemia in

Identifiers

PMID29296821
PMCPMC5728343
OpenAlexW2762872286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.