Evidence map›Paper›PMID 29296674›Full record

ArticleACS central science2017

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist.

Jeremy J Roach, Yusuke Sasano, Cullen L Schmid, Saheem Zaidi, Vsevolod Katritch, Raymond C Stevens, Laura M Bohn, Ryan A Shenvi

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Asymmetric Total Synthesis of (-)-Crotonine G and (-)-Crotonolide D.Journal of the American Chemical Society · 2025
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  15. A Protecting-Group-Free Synthesis of (-)-Salvinorin A.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jeremy J RoachDepartment of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Yusuke SasanoDepartment of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Cullen L SchmidDepartments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Saheem ZaidiDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California 90089, United States.
Vsevolod KatritchDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California 90089, United States.
Raymond C StevensDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California 90089, United States.
Laura M BohnDepartments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Ryan A ShenviDepartment of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Scripps Research Institute · USUniversity of Southern California · US

Funding

Novel Probes of the Kappa Opioid Receptor: Chemistry, Pharmacology, and BiologyR01DA031927 · NIDA · UNIVERSITY OF SOUTH FLORIDA · PI Jeffrey Aube, Laura M. Bohn · 2011 to 2026
$8.4M
Unusual Pharmacophores and New Tools for Cross-CouplingR35GM122606 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI Ryan Ashok Shenvi · 2017 to 2026
$7.1M
Structure-Function of Opioid ReceptorsP01DA035764 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEREZOV, VADIM, ROTH, BRYAN L. · 2014 to 2018
$7.1M
New Methods and Strategies for the Synthesis of Anticancer AlkaloidsR01GM104180 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SHENVI, RYAN ASHOK · 2013 to 2016
$1.4M
Synthesis of Antimalarial ICTs Using Biosynthetic LogicR01GM105766 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SHENVI, RYAN ASHOK · 2013 to 2016
$1.4M
NIDA NIH HHS P01 DA035764NIDA NIH HHS R01 DA031927NIGMS NIH HHS R01 GM104180NIGMS NIH HHS R01 GM105766NIGMS NIH HHS R35 GM122606
6 · The paper itself

Abstract

Salvinorin A (SalA) is a plant metabolite that agonizes the human

Identifiers

PMID29296674
PMCPMC5746855
OpenAlexW2771971758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.