ArticleAlzheimer's & dementia (New York, N. Y.)2018
Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis.
Article in Alzheimer's & dementia (New York, N. Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review.Drugs & aging · 2025Pooled it
- Global prevalence of polypharmacy and potentially inappropriate medication in older patients with dementia: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Interventions to Optimise Prescribing in Older People with Dementia: A Systematic Review.Drugs & aging · 2019Pooled it
- Pharmacological management in frontotemporal dementia and patient outcomes: a retrospective cohort study using the TriNetX platform.Frontiers in neurology · 2026Article
- Network analysis as a tool to illustrate the population-level complex prescribing to community-dwelling people living with dementia.International journal of population data science · 2026Article
- Impact of post-admission changes in potentially inappropriate medication use on risk of subsequent hospitalization among nursing home residents.Frontiers in pharmacology · 2025Article
- Racial and ethnic disparities in potentially inappropriate medication use in patients with dementia.Journal of the American Geriatrics Society · 2024Article
- Medication Reviews and Clinical Outcomes in Persons with Dementia: A Scoping Review.Pharmacy (Basel, Switzerland) · 2023Article
- Identifying Dynamic Patterns of Polypharmacy for Patients with Dementia from Primary Care Electronic Health Records: A Machine Learning Driven Longitudinal Study.Aging and disease · 2023Article
- Potentially Inappropriate Medication Use in Patients with Dementia.International journal of environmental research and public health · 2022Article
- Potentially Inappropriate Medications Pre- and Post-Diagnosis of Major Neurocognitive Disorders Among Older People in Sweden: A Register-Based, 6-Year Longitudinal Study.Drugs & aging · 2022Article
- Determinants of Sleep Medication Use among Participants in the National Alzheimer's Coordinating Center Uniform Data Set.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2020Article
- Potentially inappropriate prescribing in dementia: a state-of-the-art review since 2007.BMJ open · 2020Review
- The Impact of Dementia Diagnosis on Patterns of Potentially Inappropriate Medication Use Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.Alzheimer disease and associated disordersReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionPotentially inappropriate medication (PIM) use in older adults with dementia is an understudied area. We assessed longitudinal changes in PIM exposure by dementia type following dementia diagnosis.
methodsWe followed 2448 participants aged ≥65 years (52% women, 85.5% Caucasian, mean age 80.9 ± 7.5 years) diagnosed with dementia after enrollment in the National Alzheimer's Coordinating Center (2005-2014). We estimated the association between dementia type and PIM annually for 2 years after diagnosis, using Generalized Estimating Equations.
resultsParticipants with Lewy body dementia had more PIM use, and participants with frontotemporal dementia had less PIM use than participants with Alzheimer's disease. In the first year following diagnosis, total number of medications increased, on average, by 10% for Alzheimer's disease and 15% for Lewy body dementia ( DISCUSSION: A tailored approach aimed at optimizing drug therapy is needed to mitigate PIM exposure to improve medical care for individuals with dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.