ArticleNeurology(R) neuroimmunology & neuroinflammation2018
Pleocytosis is not fully responsible for low CSF glucose in meningitis.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Neurosarcoidosis as an elusive mimicker of infection and neoplasia: a case report.Journal of neurology · 2026Article
- The meninges as a neuroimmune interface: structure, barriers and roles in CNS disease.Fluids and barriers of the CNS · 2026Review
- Article
- Neurosarcoidosis in Critical Care, Internal, and Pulmonary Medicine: A Practical Approach.Seminars in respiratory and critical care medicine · 2025Review
- Hypoglycorrhachia: Unravelling the Pathogenetic Mechanisms.Indian pediatrics · 2025Article
- Pediatric bacterial meningitis in southern China: analysis of 838 cases.Frontiers in cellular and infection microbiology · 2025Article
- Glucose measurement in cerebrospinal fluid compared to peripheral blood in dogs with central nervous system disease.Frontiers in veterinary science · 2025Article
- Talaromyces marneffei central nervous system infection unveiled by the novel Mp1p antigen detection assay in AIDS patient.BMC infectious diseases · 2024Article
- Evolution of Laboratory Diagnostics for Cryptococcosis and Missing Links to Optimize Diagnosis and Outcomes in Resource-Constrained Settings.Open forum infectious diseases · 2024Review
- Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report.Frontiers in neurology · 2022Article
- Neurosarcoidosis: Pathophysiology, Diagnosis, and Treatment.Neurology(R) neuroimmunology & neuroinflammation · 2021Review
- Primary leptomeningeal lymphoma masquerading as infectious tubercular meningitis.BMJ case reports · 2021Article
- The Impact of Hyponatremia on the Severity of Childhood Tuberculous Meningitis.Frontiers in neurology · 2021Article
- AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China.AIDS research and therapy · 2020Article
- Differential Fuel Requirements of Human NK Cells and Human CD8 T Cells: Glutamine Regulates Glucose Uptake in Strongly Activated CD8 T Cells.ImmunoHorizons · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe mechanism of hypoglycorrhachia-low CSF glucose-in meningitis remains unknown. We sought to evaluate the relative contribution of CSF inflammation vs microorganisms (bacteria and fungi) in lowering CSF glucose levels.
methodsWe retrospectively categorized CSF profiles into microbial and aseptic meningitis and analyzed CSF leukocyte count, glucose, and protein concentrations. We assessed the relationship between these markers using multivariate and stratified linear regression analysis for initial and repeated CSF sampling. We also calculated the receiver operating characteristics of CSF glucose and CSF-to-serum glucose ratios to presumptively diagnose microbial meningitis.
resultsWe found that increasing levels of CSF inflammation were associated with decreased CSF glucose levels in the microbial but not aseptic category. Moreover, elevated CSF protein levels correlated more strongly than the leukocyte count with low CSF glucose levels on initial (
conclusionsThe main driver of hypoglycorrhachia appears to be a combination of microbial meningitis with moderate to high degrees of CSF inflammation and proteins, suggesting that the presence of microorganisms capable of catabolizing glucose is a determinant of hypoglycorrhachia in meningitis. A major notable exception is neurosarcoidosis. Low CSF glucose and CSF-to-serum glucose ratios are useful markers for the diagnosis of microbial meningitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.