ArticleAnnals of clinical and translational neurology2017
Clarion call for histopathological clot analysis in "cryptogenic" ischemic stroke: implications for diagnosis and treatment.
Article in Annals of clinical and translational neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Prognostic capacity of hyperdense middle cerebral artery sign in anterior circulation acute ischaemic stroke patients receiving reperfusion therapy: a systematic review and meta-analysis.Acta neurologica Belgica · 2022Pooled it
- Medicine Meets Science: The Imperative of Scientific Research and Publishing for Physician-Scientists.The Indian journal of radiology & imaging · 2025Article
- Safety and Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke Attributable to Cardiological Diseases: A Scoping Review.Journal of the American Heart Association · 2024Article
- Diagnostic Utility of N-Terminal Pro-B-Type Natriuretic Peptide in Identifying Atrial Fibrillation Post-Cryptogenic Stroke: A Systematic Review and Meta-Analysis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Bridging the Gap in Cancer-Related Stroke Management: Update on Therapeutic and Preventive Approaches.International journal of molecular sciences · 2023Review
- Clot Morphology in Acute Ischemic Stroke Decision Making.International journal of molecular sciences · 2022Review
- Is Composition of Brain Clot Retrieved by Mechanical Thrombectomy Associated with Stroke Aetiology and Clinical Outcomes in Acute Ischemic Stroke?-A Systematic Review and Meta-Analysis.Neurology international · 2022Article
- Histopathological Composition of Thrombus in Acute Ischemic Stroke May Vary Even Within the Same Patient: A Preliminary Study Examining Clots According to Their Area of Retrieval.Journal of neuroendovascular therapy · 2022Article
- A Cryptogenic Stroke Associated With Infective Endocarditis and Antiphospholipid Antibody Syndrome: Case Report and Literature Review.Frontiers in neurology · 2022Article
- Clinical outcomes following reperfusion therapy in acute ischemic stroke patients with infective endocarditis: a systematic review.Journal of central nervous system disease · 2022Review
- Imaging Clot Characteristics in Stroke and its Possible Implication on Treatment.Clinical neuroradiology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis, treatment, and secondary management of cryptogenic stroke patients pose a formidable challenge. The scenario is further complicated in patients with native and prosthetic valvular heart disease. We present a case study of a 36-year-old man who received intravenous thrombolysis (IV-tPA) and endovascular thrombectomy (EVT) for presumed "cryptogenic" complete middle cerebral artery infarction who made a surprisingly excellent clinical recovery despite poor baseline and postintervention neuroimaging. Retrospective gram stain of his clot confirmed a diagnosis of infective endocarditis. This raises an important issue regarding need for more routine histopathological analysis of clot retrieved after EVT in "cryptogenic" stroke patients particularly those with valvular heart disease.
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Registered trials
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