Evidence map›Paper›PMID 29296620›Full record

ArticleAnnals of clinical and translational neurology2017

Infectious risk stratification in multiple sclerosis patients receiving immunotherapy.

Jonas Graf, Verena I Leussink, Thomas Dehmel, Marius Ringelstein, Norbert Goebels, Ortwin Adams, Colin R MacKenzie, Clemens Warnke, Torsten Feldt, Anna Lammerskitten and 6 more

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Autoimmune Diseases and Mycobacterial Infection.Diseases (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Monoclonal Antibody Therapies Beyond Complement for NMOSD and MOGAD.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Jonas GrafDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Verena I LeussinkDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Thomas DehmelNovartis Pharma Nürnberg Germany.
Marius RingelsteinDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Norbert GoebelsDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Ortwin AdamsInstitute of Virology University Hospital Heinrich-Heine-University Düsseldorf Germany.
Colin R MacKenzieInstitute of Medical Microbiology and Hospital Hygiene University Hospital Heinrich-Heine-University Düsseldorf Germany.
Clemens WarnkeDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Torsten FeldtDepartment of Gastroenterology, Hepatology and Infectious Diseases University Hospital Heinrich-Heine-University Düsseldorf Germany.
Anna LammerskittenDepartment of Neurology University Hospital of Münster Münster Germany.
Luisa KlotzDepartment of Neurology University Hospital of Münster Münster Germany.
Sven MeuthDepartment of Neurology University Hospital of Münster Münster Germany.
Heinz WiendlDepartment of Neurology University Hospital of Münster Münster Germany.
Hans-Peter HartungDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Orhan AktasDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Philipp AlbrechtDepartment of Neurology University Hospital Medical Faculty Heinrich-Heine-University Düsseldorf Germany.
Heinrich Heine University Düsseldorf · DEDüsseldorf University Hospital · DEUniversity Hospital Münster · DENovartis (Germany) · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing number of potent treatments for multiple sclerosis warrants screening for infections. To investigate the prevalence of infections in two independent German patient cohorts with multiple sclerosis/neuromyelitis optica spectrum disorders (NMOSD), we performed a retrospective chart review study of multiple sclerosis/NMOSD patients who underwent testing for infections between 2014 and 2016. We show that 6 out of 80 tested patients (Düsseldorf cohort) and 2 out of 97 tested patients (Münster cohort) had a latent tuberculosis infection; total 3.95%, 95% CI: 2-8%. Our findings suggest that latent tuberculosis infection is frequent (>1%). Screening should be performed before embarking on immunomodulatory therapies to allow treatment and mitigation of the risk of a reactivation.

Identifiers

PMID29296620
PMCPMC5740259
OpenAlexW2768133575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.