Evidence map›Paper›PMID 29296543›Full record

ArticleOncoimmunology

IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population.

Clément Barjon, Henri-Alexandre Michaud, Angeline Fages, Cécile Dejou, Alexandre Zampieri, Laetitia They, Aurélie Gennetier, Françoise Sanchez, Laurent Gros, Jean-François Eliaou and 2 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

  1. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
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  19. Suppressive activity of Vδ2Cancer immunology, immunotherapy : CII · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Clément BarjonInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Henri-Alexandre MichaudInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Angeline FagesInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Cécile DejouOREGA Biotech, Ecully, France.
Alexandre ZampieriInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Laetitia TheyInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Aurélie GennetierInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Françoise SanchezInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Laurent GrosInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Jean-François EliaouInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Nathalie BonnefoyInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Virginie LafontInstitut de Recherche en Cancérologie de Montpellier (IRCM); INSERM, U1194; Université Montpellier; Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
Institut de Recherche en Cancérologie de Montpellier · FRInserm · FRCEA Valduc · FRCentre Technique des Industries Mécaniques · FRInstitut Regional du Cancer de Montpellier · FROREGA Biotech (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological functions of other immune cells, such as dendritic cells and IFN-γ-producing CD8

Indexed as

adenosineCD73IL-10IL-21regulatory functionstumor microenvironmentγδ T cells

Identifiers

PMID29296543
PMCPMC5739578
OpenAlexW2754261556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.