ArticleBiomedical optics express2017
Correlative three-dimensional fluorescence and refractive index tomography: bridging the gap between molecular specificity and quantitative bioimaging.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 87 citations in OpenAlex.
- Optical diffraction tomographic microscopy: a cutting-edge label-free three-dimensional bioimaging.Biophysics reports · 2026Article
- Multimodal holotomography for volumetric monitoring of host-pathogen interactions.Biomedical engineering online · 2026Article
- Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes.Nature communications · 2025Article
- Recover Biological Structure from Sparse-View Diffraction Images with Neural Volumetric Prior.Proceedings. IEEE International Conference on Computer Vision · 2025Article
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy.Communications biology · 2024Article
- Hybrid machine-learning framework for volumetric segmentation and quantification of vacuoles in individual yeast cells using holotomography.Biomedical optics express · 2023Article
- Measurement of an evaporation coefficient in tissue sections as a correction factor forHistochemistry and cell biology · 2023Article
- Quantification of structural heterogeneity in H&E stained clear cell renal cell carcinoma using refractive index tomography.Biomedical optics express · 2023Article
- Three-dimensional bi-functional refractive index and fluorescence microscopy (BRIEF).Biomedical optics express · 2022Article
- Review
- At the Intersection of Natural Structural Coloration and Bioengineering.Biomimetics (Basel, Switzerland) · 2022Review
- Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction.Biophysical journal · 2022Article
- Multiple-scattering suppressive refractive index tomography for the label-free quantitative assessment of multicellular spheroids.Biomedical optics express · 2022Article
- Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning.Nature cell biology · 2021Article
- Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia.Biosensors & bioelectronics · 2021Article
- Limited-angle tomographic phase microscopy utilizing confocal scanning fluorescence microscopy.Biomedical optics express · 2021Article
- Holotomography: Refractive Index as an Intrinsic Imaging Contrast for 3-D Label-Free Live Cell Imaging.Advances in experimental medicine and biology · 2021Article
- Article
- The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust against Strong Perturbation.Biophysical journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical diffraction tomography (ODT) provides label-free three-dimensional (3D) refractive index (RI) measurement of biological samples. However, due to the nature of the RI values of biological specimens, ODT has limited access to molecular specific information. Here, we present an optical setup combining ODT with three-channel 3D fluorescence microscopy, to enhance the molecular specificity of the 3D RI measurement. The 3D RI distribution and 3D deconvoluted fluorescence images of HeLa cells and NIH-3T3 cells are measured, and the cross-correlative analysis between RI and fluorescence of live cells are presented.
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