ArticleBiomedical optics express2017
Optical projection tomography for rapid whole mouse brain imaging.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Reconstructing Three-Dimensional Optical Anisotropy with Tomographic Müller-Polarimetric Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography.Nature communications · 2024Article
- Optical imaging of the small intestine immune compartment across scales.Communications biology · 2023Article
- Statistical distortion of supervised learning predictions in optical microscopy induced by image compression.Scientific reports · 2022Article
- Brain virtual histology with X-ray phase-contrast tomography Part II:3D morphologies of amyloid-Biomedical optics express · 2022Article
- High resolution optical projection tomography platform for multispectral imaging of the mouse gut.Biomedical optics express · 2021Article
- Article
- Soliton microcomb based spectral domain optical coherence tomography.Nature communications · 2021Article
- Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies.Frontiers in physiology · 2021Article
- zOPT: an open source optical projection tomography system and methods for rapid 3D zebrafish imaging.Biomedical optics express · 2020Article
- Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish.Journal of biophotonics · 2019Article
- OptiJ: Open-source optical projection tomography of large organ samples.Scientific reports · 2019Article
- Gaussian Light Model in Brightfield Optical Projection Tomography.Scientific reports · 2019Article
- Supervised learning to quantify amyloidosis in whole brains of an Alzheimer's disease mouse model acquired with optical projection tomography.Biomedical optics express · 2019Article
- Imaging the aged brain: pertinence and methods.Quantitative imaging in medicine and surgery · 2019Review
- Photoacoustic imaging in the second near-infrared window: a review.Journal of biomedical optics · 2019Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, three-dimensional mesoscopic imaging has gained significant importance in life sciences for fundamental studies at the whole-organ level. In this manuscript, we present an optical projection tomography (OPT) method designed for imaging of the intact mouse brain. The system features an isotropic resolution of ~50 µm and an acquisition time of four to eight minutes, using a 3-day optimized clearing protocol. Imaging of the brain autofluorescence in 3D reveals details of the neuroanatomy, while the use of fluorescent labels displays the vascular network and amyloid deposition in 5xFAD mice, an important model of Alzheimer's disease (AD). Finally, the OPT images are compared with histological slices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.