ArticleBiomedical optics express2017
Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 60 citations in OpenAlex.
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- Laser speckle size and contrast investigation of volumetric scattering from controlled turbid phantoms and mouse skin tissues.iScience · 2025Article
- Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography.Light, science & applications · 2025Article
- An open-source replication for fast and accessible light propagation modeling in brain tissue.PloS one · 2025Article
- Imaging of developing human brains with ex vivo PSOCT and dMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution.Science (New York, N.Y.) · 2024Article
- Quantification of attenuation and speckle features from endoscopic OCT images for the diagnosis of human brain glioma.Scientific reports · 2024Article
- Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography.Research square · 2024Article
- Multi-Scale Label-Free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Agarose Gel Characterization for the Fabrication of Brain Tissue Phantoms for Infrared Multispectral Vision Systems.Gels (Basel, Switzerland) · 2023Article
- Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy.Biomedical optics express · 2023Article
- Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy.Acta neuropathologica communications · 2023Article
- Quantitative optical coherence microscopy of neuron morphology in human entorhinal cortex.Frontiers in neuroscience · 2023Article
- Optical Coherence Tomography Is a Promising Tool for Zebrafish-Based Research-A Review.Bioengineering (Basel, Switzerland) · 2022Review
- Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics.Communications biology · 2022Article
- A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images.NeuroImage · 2022Article
- Research and application advances in rehabilitation assessment of stroke.Journal of Zhejiang University. Science. B · 2022Review
- Scalable mapping of myelin and neuron density in the human brain with micrometer resolution.Scientific reports · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the confocal parameter cannot be ignored. This approach enables us to quantify tissue optical properties with higher lateral resolution. The model parameter predictions for the scattering coefficients were tested with calibrated microsphere phantoms. The application of the model to human brain tissue demonstrates that the scattering and back-scattering coefficients each provide unique information, allowing us to differentially identify laminar structures in primary visual cortex and distinguish various nuclei in the midbrain. The combination of the two optical properties greatly enhances the power of OCT to distinguish intricate structures in the human brain beyond what is achievable with measured OCT intensity information alone, and therefore has the potential to enable objective evaluation of normal brain structure as well as pathological conditions in brain diseases. These results represent a promising step for enabling the quantification of tissue optical properties from high NA OCT.
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