ArticleBiomedical optics express2017
Deformation velocity imaging using optical coherence tomography and its applications to the cornea.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dynamic evaluation of corneal cross-linking and osmotic diffusion effects using optical coherence elastography.Scientific reports · 2024Article
- Rapid imaging and product screening with low-cost line-field Fourier domain optical coherence tomography.Scientific reports · 2023Article
- Spatio-Temporal Dynamics of Diffusion-Associated Deformations of Biological Tissues and Polyacrylamide Gels Observed with Optical Coherence Elastography.Materials (Basel, Switzerland) · 2023Article
- Retinal and Corneal Changes Associated with Intraocular Silicone Oil Tamponade.Journal of clinical medicine · 2022Review
- Accurate In Vivo Bowman's Thickness Measurement Using Mirau Ultrahigh Axial Resolution Line Field Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Optical Coherence Elastography as a Tool for Studying Deformations in Biomaterials: Spatially-Resolved Osmotic Strain Dynamics in Cartilaginous Samples.Materials (Basel, Switzerland) · 2022Article
- Simulating scan formation in multimodal optical coherence tomography: angular-spectrum formulation based on ballistic scattering of arbitrary-form beams.Biomedical optics express · 2021Article
- Line-Field Optical Coherence Tomography as a tool for In vitro characterization of corneal biomechanics under physiological pressures.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.