ArticleBiomedical optics express2017
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Dynamic Windkessel autoregulation for optical hemodynamic imaging: quantifying microcirculation, oxygen diffusion, and vascular autoregulation from low-frequency hemodynamic oscillations.Biomedical optics express · 2026Article
- Development and characterization of a combined fluorescence and spatial frequency domain imaging system for real-time dosimetry of photodynamic therapy.Journal of biomedical optics · 2025Article
- Deep-learning-enabled spatial frequency domain imaging of the spatiotemporal dynamics of skin physiology.Journal of biomedical optics · 2025Article
- Multi-frequency spatial frequency domain imaging: a depth-resolved optical scattering model to isolate scattering contrast in thin layers of skin.Journal of biomedical optics · 2024Article
- Multiexposure laser speckle contrast analysis system calibration limited by perfusion-dependent scattering on the skin.Journal of biomedical optics · 2023Article
- Development of a platform for broadband, spectra-fitted, tissue optical phantoms.Journal of biomedical optics · 2023Article
- Geometry design for a fully insertable glucose biosensor with multimodal optical readout.Journal of biomedical optics · 2022Article
- Spectral imaging of normal, hydrated, and desiccated porcine skin using polarized light.Journal of biomedical optics · 2022Article
- Wavelength and frequency optimization in spatial frequency domain imaging for two-layer tissue.Biomedical optics express · 2022Article
- Monte Carlo method for assessment of a multimodal insertable biosensor.Journal of biomedical optics · 2022Article
- [An optical parameter imaging system with profile information fusion].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Multimodal hyperspectral fluorescence and spatial frequency domain imaging for tissue health diagnostics of the oral cavity.Biomedical optics express · 2021Article
- Article
- Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity.Biomedical optics express · 2021Article
- Handheld spatial frequency domain imager for noninvasive Sjögren's syndrome labial salivary gland biopsy.Biomedical optics express · 2021Article
- Modeling and Synthesis of Breast Cancer Optical Property Signatures With Generative Models.IEEE transactions on medical imaging · 2021Article
- Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring.Biomedical optics express · 2021Article
- Single snapshot spatial frequency domain imaging for risk stratification of diabetes and diabetic foot.Biomedical optics express · 2020Article
- Dynamic microcirculation PIPE model for functional neuroimaging, non-neuroimaging, and coherent hemodynamics spectroscopy: blood volume and flow velocity variations, and vascular autoregulation.Biomedical optics express · 2020Article
- Analysis of skin morphological features and real-time monitoring using snapshot hyperspectral imaging.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the real-time single snapshot multiple frequency demodulation - spatial frequency domain imaging (SSMD-SFDI) platform implemented with a visible digital mirror device that is capable of imaging and monitoring dynamic turbid medium and processes over a large field of view. One challenge in quantitative imaging of biological tissue such as the skin is the complex structure rendering techniques based on homogeneous medium models to fail. To address this difficulty we have also developed a novel method that maps the layered structure to a homogeneous medium for spatial frequency domain imaging. The varying penetration depth of spatially modulated light on its wavelength and modulation frequency is used to resolve the layered structure. The efficacy of the real-time SSMD-SFDI platform and this two-layer model is demonstrated by imaging forearms of 6 healthy subjects under the reactive hyperemia protocol. The results show that our approach not only successfully decouples light absorption by melanin from that by hemoglobin and yields accurate determination of cutaneous hemoglobin concentration and oxygen saturation, but also provides reliable estimation of the scattering properties, the melanin content and the epidermal thickness in real time. Potential applications of our system in imaging skin physiological and functional states, cancer screening, and microcirculation monitoring are discussed at the end.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.