Evidence map›Paper›PMID 29296450›Full record

ArticleJournal of radiosurgery and SBRT2017

Relapsed or refractory primary central nervous system lymphoma radiosurgery: Report of the International Gamma Knife Research Foundation.

Samuel M Shin, Joshua S Silverman, Greg Bowden, David Mathieu, Huai-Che Yang, Cheng-Chia Lee, Moses Tam, Paul Szelemej, Anthony M Kaufmann, Or Cohen-Inbar and 4 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of radiosurgery and SBRT, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Samuel M ShinDepartment of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, NY 10016, USA.
Joshua S SilvermanDepartment of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, NY 10016, USA.
Greg BowdenDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
David MathieuDepartment of Neurosurgery, Université de Sherbrooke, Sherbrooke, QC, Canada, J1K 2R1.
Huai-Che YangDepartment of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan 112.
Cheng-Chia LeeDepartment of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan 112.
Moses TamDepartment of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, NY 10016, USA.
Paul SzelemejSection of Neurosurgery, University of Manitoba, Winnipeg, MB, Canada, R3A 1R9.
Anthony M KaufmannSection of Neurosurgery, University of Manitoba, Winnipeg, MB, Canada, R3A 1R9.
Or Cohen-InbarDepartment of Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jason SheehanDepartment of Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ajay NiranjanDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
L Dade LunsfordDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Douglas KondziolkaDepartment of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, NY 10016, USA.
Neurological Surgery · USUniversity of Virginia · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic radiosurgery (SRS) can be used as part of multimodality management for patients with primary central nervous system lymphoma (PCNSL). The objective of this study is to evaluate outcomes of SRS for this disease. The International Gamma Knife Research Foundation identified 23 PCNSL patients who underwent SRS for either relapsed (intracerebral in-field or out-of-field tumor recurrences) or refractory disease from 1995-2014. All 23 patients presented with RPA Class I or II PCNSL, and were initially treated with a median of 7 cycles of methotrexate-based chemotherapy regimens (range, 3-26 cycles). Ten received prior whole brain radiation (WBRT) to a median dose of 43 Gy (range, 24-55 Gy). Sixteen presented with relapsed PCNSL, and seven presented with refractory disease. Twenty-three received 26 procedures of SRS. The median tumor volume was 4 cm

Indexed as

International Gamma Knife Research Foundationprimary central nervous system lymphomaradiosurgerysalvage

Identifiers

PMID29296450
PMCPMC5658820
OpenAlexW2946903114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.