ArticleJournal of radiosurgery and SBRT2015
Equivalent whole brain dose for patients undergoing gamma knife for multiple lesions.
Article in Journal of radiosurgery and SBRT, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Management of patients with brain metastases from NSCLC without a genetic driver alteration: upfront radiotherapy or immunotherapy?Therapeutic advances in medical oncology · 2023Review
- Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors.Clinical & experimental metastasis · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe advent of new radiosurgical technology has enabled the treatment of patients with larger numbers of brain metastases. At what point the whole brain doses delivered in single fraction radiosurgical treatment begin to approximate a fraction of whole brain radiotherapy is unknown. Measuring the equivalent whole-brain dose for multiple lesions may yield useful clinical insights.
methodsTwelve representative patients were chosen from our institutional database, having undergone radiosurgery for multiple lesions. All patients were treated using the Leksell Gamma Knife Perfexion radiosurgical platform. The entire brain was contoured and mean whole brain dose (MWBD) was calculated. For each plan, all enhancing tumors were outlined and total volume of tumors recorded.
resultsA total of 33 treatments were administered. Three patients underwent radiosurgery a single time, one patient on two occasions, four patients on three occasions, and four patients on four occasions. Median number of lesions treated was 8 (range 1-41). Dose ranged from 18-22 Gy per lesion. The median MWBD per treatment was 1.4 Gy (range 0.2-7.6 Gy). Median total tumor volume was 4.3 cm
conclusionBoth tumor number and volume were associated with increased MWBD. Patients with greater than 25 lesions treated per session or cumulative tumor volumes greater than 10 cm
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Identifiers
29296401PMC5746333W2995505173What OpenQuestion holds
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