Evidence map›Paper›PMID 29296089›Full record

ArticleJournal of asthma and allergy2018

Elevated fractional exhaled nitric oxide and blood eosinophil counts are associated with a 17q21 asthma risk allele in adult subjects.

Elizabeth A Schwantes, Michael D Evans, Alex Cuskey, Alex Burford, Judith A Smith, Robert F Lemanske, Nizar N Jarjour, Sameer K Mathur

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of asthma and allergy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Orosomucoid-like protein 3, rhinovirus and asthma.World journal of critical care medicine · 2021
    Review
  2. Mechanisms Targeting the Unfolded Protein Response in Asthma.American journal of respiratory cell and molecular biology · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Elizabeth A SchwantesDivision of Allergy, Pulmonary and Critical Care, Department of Medicine.
Michael D EvansDepartment of Biostatistics and Medical Informatics.
Alex CuskeyDivision of Allergy, Pulmonary and Critical Care, Department of Medicine.
Alex BurfordDivision of Allergy, Pulmonary and Critical Care, Department of Medicine.
Judith A SmithDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Robert F LemanskeDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nizar N JarjourDivision of Allergy, Pulmonary and Critical Care, Department of Medicine.
Sameer K MathurDivision of Allergy, Pulmonary and Critical Care, Department of Medicine.
Pulmonary and Allergy Associates · USUniversity of Wisconsin–Madison · USInstitute for Medical Informatics and Biostatistics · CH

Funding

Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
Thr Role of Pin1 in AirwayP01HL088594 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2008 to 2017
$21.0M
Regulation of human immune function by 17q21 asthma risk polymorphismR21AI121808 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, JUDITH ANNE · 2016 to 2017
$421k
Eosinophil beta1 integrin activation as a biomarker for eosinophilic esophagitisR21AI122103 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MATHUR, SAMEER K · 2016 to 2017
$421k
NHLBI NIH HHS P01 HL070831NHLBI NIH HHS P01 HL088594NIAID NIH HHS R21 AI121808NIAID NIH HHS R21 AI122103
6 · The paper itself

Abstract

BACKGROUND AND

objectivesGenome-wide association studies identified single-nucleotide polymorphisms (SNPs) at the 17q21 locus conferring increased risk for childhood-onset asthma. Little is known about how these SNPs impact adult asthma patients. We sought to examine an adult population for associations between rs7216389 (17q21-associated SNP) and features of asthma including fractional exhaled nitric oxide (FeNO), eosinophil counts, and age of asthma onset.

methodsSubjects were genotyped at SNP rs7216389. The geometric mean of FeNO measurements and peripheral blood eosinophil counts from 2008 to 2015 were collected. Demographics and medical history were collected including self-reported allergy diagnoses and age of asthma onset. Eosinophils, monocytes, and peripheral blood mononuclear cells (PBMCs) were isolated for the examination of ORMDL3 expression.

resultsFeNO levels from 157 genotyped subjects (31CC, 72CT, and 54TT) and peripheral eosinophil counts from 252 genotyped subjects (46CC, 122CT, and 84TT) were analyzed. In a sub-group analysis of asthma subjects, the number of attributable T alleles was associated with significantly lower age of asthma onset (

conclusionIn adult subjects, the number of T alleles at SNP rs7216389 corresponds to significantly greater FeNO levels and peripheral eosinophil counts. The expression of ORMDL3 in eosinophils suggests that they may participate in mediating the asthma risk associated with the 17q21 locus.

Indexed as

17q21asthmaeosinophilsfractional exhaled nitric oxide

Identifiers

PMID29296089
PMCPMC5741070
OpenAlexW2781300401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.