A targeted approach to genome-wide studies reveals new genetic associations with central corneal thickness.

Matthew D Benson, Chiea C Khor, Philip J Gage, Ordan J Lehmann

Open access · greenAbstract read

In one paragraph

Article in Molecular vision, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

1.3field-weighted citation impact, top 16% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers.Journal of neuroscience research · 2021
Article
Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment.Journal of ophthalmology · 2020
Review
Network-Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensitivity in Mice.G3 (Bethesda, Md.) · 2019
Article
Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO).Experimental eye research · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Matthew D BensonDepartment of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada.

Chiea C KhorGenome Institute of Singapore, Singapore.

Philip J GageDepartment of Ophthalmology and Visual Science, Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI.

Ordan J LehmannDepartment of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada.

University of Alberta · CAGenome Institute of Singapore · SG

Funding

Pitx2: Molecular mechanisms in eye development &diseaseR01EY014126 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAGE, PHILIP J · 2002 to 2020

$6.4M

NEI NIH HHS R01 EY014126

6 · The paper itself

Abstract

Purpose: To evaluate the ability of a targeted genome-wide association study (GWAS) to identify genes associated with central corneal thickness (CCT). Methods: A targeted GWAS was used to investigate whether ten candidate genes with known roles in corneal development were associated with CCT in two Singaporean populations. The single nucleotide polymorphisms (SNPs) within a 500 kb interval encompassing each candidate were analyzed, and in light of the resulting data, members of the Wnt pathway were subsequently screened using similar methodology. Results: Variants within the 500 kb interval encompassing three candidate genes, Conclusions: The targeted GWAS identified four genes (

Indexed as

Genome-Wide Association StudyPolymorphism, Single NucleotideQuantitative Trait, HeritableAnimalsAsian PeopleCorneaCorneal PachymetryFemaleForkhead Box Protein O1HumansIndiaIntercellular Signaling Peptides and ProteinsMalaysiaMaleMiceMice, Inbred C57BLDKK1 protein, humanDKK2 protein, humanForkhead Box Protein O1FOXO1 protein, humanFzd8 protein, humanIntercellular Signaling Peptides and ProteinsReceptors, Cell SurfaceTCF7L2 protein, humanTranscription Factor 7-Like 2 Protein

Identifiers

PMID29296075

PMCPMC5741379

OpenAlexW2778299099

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.