ArticleJournal of medical physics
Grid Block Design Based on Monte Carlo Simulated Dosimetry, the Linear Quadratic and Hug-Kellerer Radiobiological Models.
Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Implementation of VMAT-based lattice spatially fractionated radiation therapy (SFRT) across linac platforms: Practical considerations for QA and motion management.Journal of applied clinical medical physics · 2026Article
- Lattice Radiation Therapy Plays a Synergistic Role in the Radical Treatment of Bulky Cervical Cancer: A Case Report and Literature Review.Current oncology (Toronto, Ont.) · 2026Review
- Technical evaluation of non-coplanar lattice radiotherapy: achieving directional VPDR uniformity with a 5-mm leaf width multi-leaf collimator.Frontiers in oncology · 2026Article
- Modeling the impact of intercellular signaling on dose metrics and therapeutic outcomes in spatially fractionated radiation therapy (SFRT) for lung cancer.Scientific reports · 2025Article
- Complete Dosimetric Characterization of an In-House Manufactured SFRT Grid Collimator by 3D Printing with PLA-W Composite Filament.Polymers · 2025Article
- Bystander Response Following High-Dose X-irradiation; Time-dependent Nature of GammaH2AX Foci and Cell Death Consequences.Journal of biomedical physics & engineering · 2023Article
- Feasibility of lattice radiotherapy using proton and carbon-ion pencil beam for sinonasal malignancy.Annals of translational medicine · 2022Article
- The dosimetric enhancement of GRID profiles using an external collimator in pencil beam scanning proton therapy.Medical physics · 2022Article
- Optimizing proton minibeam radiotherapy by interlacing and heterogeneous tumor dose on the basis of calculated clonogenic cell survival.Scientific reports · 2021Article
- A Current Review of Spatial Fractionation: Back to the Future?International journal of radiation oncology, biology, physics · 2019Review
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Authors and funding
6 authors.
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Abstract
purposeThe clinical efficacy of Grid therapy has been examined by several investigators. In this project, the hole diameter and hole spacing in Grid blocks were examined to determine the optimum parameters that give a therapeutic advantage.
methodsThe evaluations were performed using Monte Carlo (MC) simulation and commonly used radiobiological models. The Geant4 MC code was used to simulate the dose distributions for 25 different Grid blocks with different hole diameters and center-to-center spacing. The therapeutic parameters of these blocks, namely, the therapeutic ratio (TR) and geometrical sparing factor (GSF) were calculated using two different radiobiological models, including the linear quadratic and Hug-Kellerer models. In addition, the ratio of the open to blocked area (ROTBA) is also used as a geometrical parameter for each block design. Comparisons of the TR, GSF, and ROTBA for all of the blocks were used to derive the parameters for an optimum Grid block with the maximum TR, minimum GSF, and optimal ROTBA. A sample of the optimum Grid block was fabricated at our institution. Dosimetric characteristics of this Grid block were measured using an ionization chamber in water phantom, Gafchromic film, and thermoluminescent dosimeters in Solid Water™ phantom materials.
resultsThe results of these investigations indicated that Grid blocks with hole diameters between 1.00 and 1.25 cm and spacing of 1.7 or 1.8 cm have optimal therapeutic parameters (TR > 1.3 and GSF~0.90). The measured dosimetric characteristics of the optimum Grid blocks including dose profiles, percentage depth dose, dose output factor (cGy/MU), and valley-to-peak ratio were in good agreement (±5%) with the simulated data.
conclusionIn summary, using MC-based dosimetry, two radiobiological models, and previously published clinical data, we have introduced a method to design a Grid block with optimum therapeutic response. The simulated data were reproduced by experimental data.
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