SynthesisJournal of perinatology : official journal of the California Perinatal Association2018
Automated versus manual control of inspired oxygen to target oxygen saturation in preterm infants: a systematic review and meta-analysis.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Automated Oxygen Control (Closed Loop Inspired Oxygen:CLiO2™) With and Without Automated Pressure Control (Volume Guarantee®) in Preterm Ventilated Infants: A Crossover Study (CLIO-VG Study)
Randomized Crossover Trial to Compare Closed-loop FiO2 Controller With Conventional Control of FiO2 During Mechanical Ventilation of Pediatric Patients
Randomized Crossover Trial To Compare Closed-loop FiO2 Controller With Conventional Control of FiO2 During High Flow Oxygen Treatment In Pediatric Intensive Care Unit Patients
Automated Oxygen Control for Preterm Infants On Continuous Positive Airway Pressure (CPAP): Phase 1/2 Trial In Southwest Nigeria
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.Neonatology · 2019Guideline
- Closed-loop automated oxygen control in late preterm and term, ventilated infants: A randomised controlled trial.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- Pulse oximetry signal loss during hypoxic episodes in preterm infants receiving automated oxygen control.European journal of pediatrics · 2024Trial
- Trial
- Evaluation of two SpOBMC pediatrics · 2019Trial
- Noninvasive oxygenation monitoring in PPHN: validation of the oxygen saturation index and the oxygen saturation to fraction of inspired oxygen ratio against conventional invasive indices.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Automated oxygen control versus manual titration in preterm infants: A systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Closed-Loop Automated Oxygen Control in Preterm Infants Receiving Non-Invasive Respiratory Support.Children (Basel, Switzerland) · 2025Review
- [Application of intelligent oxygen management system in neonatal intensive care units: a scoping review].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Article
- The effectiveness of automated adjustment of inspired oxygen in preterm infants receiving respiratory support compared with manual: A systematic review and meta-analysis.Pediatric discovery · 2024Review
- Statistical analysis plan for the FiOTrials · 2024Article
- Occurrence of hyperoxia during iNO treatment for persistent pulmonary hypertension of the newborn: a cohort study.European journal of pediatrics · 2024Article
- Closed-loop oxygen usage during invasive mechanical ventilation of pediatric patients (CLOUDIMPP): a randomized controlled cross-over study.Frontiers in medicine · 2024Article
- Closed-loop automated oxygen control in ventilated infants born at or near term: A crossover trial.Acta paediatrica (Oslo, Norway : 1992) · 2023Article
- Clinical Evaluation of an Automatic Oxygen Control System for Premature Infants Receiving High-Flow Nasal Cannula for Respiratory Support: A Pilot Study.Journal of medical devices · 2022Article
- Frequency and duration of extreme hypoxemic and hyperoxemic episodes during manual and automatic oxygen control in preterm infants: a retrospective cohort analysis from randomized studies.BMC pediatrics · 2022Article
- Decoupling Oxygen Tension From Retinal Vascularization as a New Perspective for Management of Retinopathy of Prematurity. New Opportunities From β-adrenoceptors.Frontiers in pharmacology · 2022Review
- Closed-loop oxygen control improves oxygenation in pediatric patients under high-flow nasal oxygen-A randomized crossover study.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo conduct a systematic review of clinical trials comparing automated versus manual fraction of inspired oxygen (FiO
designThe authors searched MEDLINE, Embase, CENTRAL, and CINAHL from inception upto December 2016, reviewed conference proceedings and sought results of unpublished trials. Studies were included if automated FiO
resultsOut of 276 identified studies 10 met the inclusion criteria. Automated FiO
conclusionAutomated FiO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.