ArticleJournal of exposure science & environmental epidemiology2018
Exposure to tobacco smoke and validation of smoking status during pregnancy in the MIREC study.
Article in Journal of exposure science & environmental epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- Cord Blood Adductomic Profiling Provides Preliminary Insights on Perinatal Smoking Exposure: A Pilot Analysis.Antioxidants (Basel, Switzerland) · 2026Article
- Insights into the validity of concurrent and retrospective maternal report of infant smoke exposure using biomarker-based validation.Pediatric research · 2026Article
- Chemical mixtures and birth weight: comparison of multipollutant models in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.Environmental health : a global access science source · 2026Article
- Examination of DNA Methylation Patterns in Children Born Premature with Prenatal Tobacco Smoke Exposure.Toxics · 2025Article
- Prenatal PFAS exposures and cardiometabolic health in middle childhood in the MIREC cohort.Environmental research · 2025Article
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- Robust tobacco smoking self-report in two cohorts: pregnant women or men and women living with or without HIV.Scientific reports · 2023Article
- Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.Environmental health perspectives · 2023Article
- Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.International journal of environmental research and public health · 2022Article
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- Predictors of Secondhand Smoke Exposure During Pregnancy in Costa Rica, the Dominican Republic, and Honduras.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children's Study (JECS).International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Given that prenatal exposure to tobacco smoke can lead to increased risks of adverse health effects, having valid measures of exposure is important. In a Canadian cohort (n = 2000), maternal and infant biospecimens were analysed for cotinine. Sensitivity and specificity of self-reported active smoking status were estimated. Regression modelling was used to identify potential predictors of maternal and infant plasma cotinine in non-smoking women. During the first trimester, 60.6% of the women reported never smoking, 27.3% were former smokers, 6.1% had quit when they found out they were pregnant, 5.8% were smokers and 42% of the non-smokers reported exposure to secondhand smoke (SHS). Low detection of tobacco biomarkers in meconium limited its ability to identify exposure to SHS. The sensitivity and specificity for self-reported smoking during the 1st trimester were 85.37 and 99.45%, respectively. The lowest sensitivity was found in participants with the highest level of education and income, oldest women and those born outside Canada. Non-smoking women living in an apartment had 1.7 times higher odds of detectable plasma cotinine than those living in a single home after adjusting for other variables. Our results suggest that while self-reports are fairly accurate, they may be less so in populations with higher socio-economic status. This investigation underscores the need to consider the participant socio-economic characteristics and dwelling type when using questionnaires to estimate active and passive tobacco exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.