ArticleNature communications2018
Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Discovery of natural products that modulate signaling in patient-derived cells.RSC chemical biology · 2026Article
- Spirocyclic β-lactone secondary metabolites modulate spliceosome function.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multiplexed Immunophenotyping for Innate Activation Assessment Detects Single-Cell Responses to Immunomodulatory Nucleic Acid Impurities in Therapeutics.The AAPS journal · 2026Article
- Isolation and genomic analysis of secondary metabolism in cave Actinomycetota from biofilms andmicroPublication biology · 2026Article
- Isolation and genomic analysis of secondary metabolism in cave Actinomycetota from biofilms andbioRxiv : the preprint server for biology · 2025Article
- Connecting chemical structure to single cell signaling profiles.Communications biology · 2025Article
- TET2-loss enhances immediate and time-resolved interferon-γ signaling responses across myeloid differentiation.Experimental hematology · 2025Article
- Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete.The Journal of antibiotics · 2025Article
- Multiplexed cytometry for single cell chemical biology.Methods in cell biology · 2025Article
- Review
- Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation.Blood advances · 2024Article
- Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products.Natural product reports · 2024Review
- The isolation strategy and chemical analysis of oil cells from Asari Radix et Rhizoma.Plant methods · 2024Article
- Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters.RSC advances · 2023Review
- Metabolic profiling identifies the significance of caffeine metabolism in CKD.Frontiers in bioengineering and biotechnology · 2023Article
- On the importance for drug discovery of a transnational Latin American database of natural compound structures.Frontiers in pharmacology · 2023Article
- Systems Immunology Analyses ofImmunoHorizons · 2022Article
- Isocitrate dehydrogenase mutations are associated with altered IL-1β responses in acute myeloid leukemia.Leukemia · 2022Article
- Synthetic Biology Advanced Natural Product Discovery.Metabolites · 2021Review
- DebarcodeR increases fluorescent cell barcoding capacity and accuracy.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Discovering bioactive metabolites within a metabolome is challenging because there is generally little foreknowledge of metabolite molecular and cell-targeting activities. Here, single-cell response profiles and primary human tissue comprise a response platform used to discover novel microbial metabolites with cell-type-selective effector properties in untargeted metabolomic inventories. Metabolites display diverse effector mechanisms, including targeting protein synthesis, cell cycle status, DNA damage repair, necrosis, apoptosis, or phosphoprotein signaling. Arrayed metabolites are tested against acute myeloid leukemia patient bone marrow and molecules that specifically targeted blast cells or nonleukemic immune cell subsets within the same tissue biopsy are revealed. Cell-targeting polyketides are identified in extracts from biosynthetically prolific bacteria, including a previously unreported leukemia blast-targeting anthracycline and a polyene macrolactam that alternates between targeting blasts or nonmalignant cells by way of light-triggered photochemical isomerization. High-resolution cell profiling with mass cytometry confirms response mechanisms and is used to validate initial observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.