Evidence map›Paper›PMID 29295981›Full record

ArticleNature communications2018

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis.

Kimitoshi Kimura, Hirohiko Hohjoh, Masashi Fukuoka, Wakiro Sato, Shinji Oki, Chiharu Tomi, Hiromi Yamaguchi, Takayuki Kondo, Ryosuke Takahashi, Takashi Yamamura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.

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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kimitoshi KimuraDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Hirohiko HohjohDepartment of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Masashi FukuokaDepartment of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Wakiro SatoDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Shinji OkiDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Chiharu TomiDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Hiromi YamaguchiDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Takayuki KondoDepartment of Neurology, Kyoto University Graduate School of Medicine, Yoshida-konoe-cho, Sakyo, Kyoto, 606-8501, Japan.
Ryosuke TakahashiDepartment of Neurology, Kyoto University Graduate School of Medicine, Yoshida-konoe-cho, Sakyo, Kyoto, 606-8501, Japan.
Takashi YamamuraDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. yamamura@ncnp.go.jp.
National Center of Neurology and Psychiatry · JPKansai Medical University · JPKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3

Indexed as

AdultCD4-Positive T-LymphocytesExosomesFemaleForkhead Transcription FactorsHumansInterleukin-17MaleMicroRNAsMiddle AgedMultiple SclerosisProtein Serine-Threonine KinasesReceptor, IGF Type 1Receptors, SomatomedinReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IForkhead Transcription FactorsFOXP3 protein, humanIGF1R protein, humanIL17A protein, humanInterleukin-17MicroRNAsmirnlet7 microRNA, humanProtein Serine-Threonine KinasesReceptor, IGF Type 1Receptors, SomatomedinReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type ITGFBR1 protein, human

Identifiers

PMID29295981
PMCPMC5750223
OpenAlexW2781432284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.