ArticleNature communications2018
Extreme sensitivity to ultraviolet light in the fungal pathogen causing white-nose syndrome of bats.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Fungal DNA damage repair: from model to driver of virulence and AMR.Bioscience reports · 2026Review
- Transcriptomic and Metabolomic Insights into the Inhibitory Mechanisms of Bat Cave Soil Microbial Volatiles AgainstMicroorganisms · 2026Article
- Occupancy and activity patterns of a newly white-nose syndrome infected species in Texas, the Tricolored Bat (Journal of mammalogy · 2026Article
- Inhibitory and synergistic effects of volatile organic compounds from bat caves againstmSystems · 2026Article
- Article
- Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi.Angewandte Chemie (International ed. in English) · 2025Article
- Beyond White-Nose Syndrome: Mitochondrial and Functional Genomics ofJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- Unraveling the ancient fungal DNA from the Iceman gut.BMC genomics · 2024Article
- The skin I live in: Pathogenesis of white-nose syndrome of bats.PLoS pathogens · 2024Review
- Expanding the Toolbox for Genetic Manipulation inJournal of fungi (Basel, Switzerland) · 2024Article
- Contact-independent exposure toPeerJ · 2023Article
- Article
- Forgotten fungi: the importance of the skin mycobiome.Current opinion in microbiology · 2022Review
- Gaussian process forecastsEcology and evolution · 2022Article
- Evaluation of Virus-Free and Wild-Type Isolates ofmSphere · 2022Article
- Development of a multi-year white-nose syndrome mitigation strategy using antifungal volatile organic compounds.PloS one · 2022Article
- Trans-2-hexenal downregulates several pathogenicity genes of Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats.Journal of industrial microbiology & biotechnology · 2021Article
- Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bat white-nose syndrome (WNS), caused by the fungal pathogen Pseudogymnoascus destructans, has decimated North American hibernating bats since its emergence in 2006. Here, we utilize comparative genomics to examine the evolutionary history of this pathogen in comparison to six closely related nonpathogenic species. P. destructans displays a large reduction in carbohydrate-utilizing enzymes (CAZymes) and in the predicted secretome (~50%), and an increase in lineage-specific genes. The pathogen has lost a key enzyme, UVE1, in the alternate excision repair (AER) pathway, which is known to contribute to repair of DNA lesions induced by ultraviolet (UV) light. Consistent with a nonfunctional AER pathway, P. destructans is extremely sensitive to UV light, as well as the DNA alkylating agent methyl methanesulfonate (MMS). The differential susceptibility of P. destructans to UV light in comparison to other hibernacula-inhabiting fungi represents a potential "Achilles' heel" of P. destructans that might be exploited for treatment of bats with WNS.
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