Evidence map›Paper›PMID 29295930›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Identification of a ubiquitin-binding interface using Rosetta and DEER.

Maxx H Tessmer, David M Anderson, Adam M Pickrum, Molly O Riegert, Rocco Moretti, Jens Meiler, Jimmy B Feix, Dara W Frank

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Protein Modeling with DEER Spectroscopy.Annual review of biophysics · 2025
    Review
  4. Article
  5. Modeling of Cu(II)-based protein spin labels using rotamer libraries.Physical chemistry chemical physics : PCCP · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. UtilizingBiochemistry and biophysics reports · 2022
    Article
  11. Article
  12. Perspectives on theToxins · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Microorganisms · 2019
    Review
  19. Interactions of the effector ExoU fromThe Journal of biological chemistry · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maxx H TessmerDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226.
David M AndersonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232.
Adam M PickrumDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226.
Molly O RiegertDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226.
Rocco MorettiDepartment of Chemistry, Vanderbilt University, Nashville, TN 37232.
Jens MeilerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232.
Jimmy B FeixDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226.
Dara W FrankDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226; frankd@mcw.edu.
Medical College of Wisconsin · USVanderbilt University · US

Funding

TR&D Project 3P41EB001980 · NIBIB · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2003 to 2017
$16.3M
ROSETTA An Integrated Protein Structure Modeling SuiteR01GM073151 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A · 2005 to 2019
$7.8M
Type III effector-cofactor dynamics within the cellular environmentR01AI104922 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI FEIX, JIMMY, FRANK, DARA W. · 2013 to 2021
$3.7M
Membrane Protein Structure Elucidation from sparse NMR data (KAMP)R01GM080403 · NIGMS · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2007 to 2019
$3.0M
Mechanism of Activation and Membrane Interactions of Pseudomonas toxin ExoUR01GM114234 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI FEIX, JIMMY · 2015 to 2018
$1.2M
Acquisition of a Bruker E580 Pulse EPR SpectrometerS10RR022422 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2007 to 2007
$500k
Acquisition of Q-band Pulsed EPR CapabilityS10OD011937 · OD · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2012 to 2012
$381k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NCRR NIH HHS S10 RR022422NIAID NIH HHS R01 AI104922NIBIB NIH HHS P41 EB001980NIGMS NIH HHS R01 GM073151NIGMS NIH HHS R01 GM080403NIGMS NIH HHS R01 GM114234NIH HHS S10 OD011937
6 · The paper itself

Abstract

ExoU is a type III-secreted cytotoxin expressing A

Indexed as

Bacterial ProteinsCrystallography, X-RayElectron Spin Resonance SpectroscopyModels, MolecularProtein BindingProtein DomainsPseudomonas aeruginosaUbiquitinBacterial Proteinspseudomonas exoprotein A protein, Pseudomonas aeruginosaUbiquitincomputational modelingcontinuous-wave spectroscopyDEERRosettaubiquitin-binding domain

Identifiers

PMID29295930
PMCPMC5776994
OpenAlexW2782427638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.