Evidence map›Paper›PMID 29295820›Full record

ArticleJournal of lipid research2018

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants.

Jessica M Lee, Jessica R Ong, Laurent Vergnes, Thomas Q de Aguiar Vallim, Jonathan Nolan, Rita M Cantor, Julian R F Walters, Karen Reue

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  8. Review
  9. Functional, Diagnostic and Therapeutic Aspects of Bile.Clinical and experimental gastroenterology · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. The Role of Bile Acids in Chronic Diarrhea.The American journal of gastroenterology · 2020
    Review
  15. Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG).American journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
  16. Article
  17. Review
  18. Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Review
  19. Chronic diarrhea, bile acids, and Clostridia.The Journal of clinical investigation · 2020
    Article
  20. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jessica M LeeDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA.
Jessica R OngDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA.
Laurent VergnesDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA.
Thomas Q de Aguiar VallimDepartment of Biological Chemistry and Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Jonathan NolanDepartment of Medicine, Section of Hepatology and Gastroenterology, Imperial College London and Imperial College Healthcare, London, United Kingdom.
Rita M CantorDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA.
Julian R F WaltersDepartment of Medicine, Section of Hepatology and Gastroenterology, Imperial College London and Imperial College Healthcare, London, United Kingdom.
Karen ReueDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA reuek@ucla.edu.
University of California, Los Angeles · USImperial College Healthcare NHS Trust · GBImperial College London · GB

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 1985 to 2019
$50.2M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Characterization of Diet1, a hypercholesterolemia resistance geneR01HL102661 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2010 to 2013
$1.5M
NHLBI NIH HHS P01 HL028481NHLBI NIH HHS R01 HL102661Wellcome Trust
6 · The paper itself

Abstract

Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous

Indexed as

Disease Models, AnimalAdultAgedAged, 80 and overAnimalsBile Acids and SaltsCarrier ProteinsDiarrheaFemaleFibroblast Growth FactorsGenetic VariationGenotypeHumansMaleMiceMice, Inbred C57BLBile Acids and SaltsCarrier ProteinsDiet1 protein, mouseFibroblast Growth Factorsfibroblast growth factor 15/19Hybrid Mouse Diversity Panelintestine

Identifiers

PMID29295820
PMCPMC5832924
OpenAlexW2781514429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.