Evidence map›Paper›PMID 29295509›Full record

ReviewInternational journal of environmental research and public health2017

Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus.

Sugunadevi Sakkiah, Tony Wang, Wen Zou, Yuping Wang, Bohu Pan, Weida Tong, Huixiao Hong

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. The impact of Tai Chi on osteoporosis and osteopenia in middle-aged and elderly adults: a systematic review and meta-analysis of randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
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  7. Antioxidants (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sugunadevi SakkiahNational Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Suguna.Sakkiah@fda.hhs.gov.
Tony WangDepartment of Biology, Arkansas University, Fayetteville, AR 72701, USA. tonywang@email.uark.edu.
Wen ZouNational Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Wen.Zou@fda.hhs.gov.
Yuping WangNational Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Yuping.Wang@fda.hhs.gov.
Bohu PanNational Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Bohu.Pan@fda.hhs.gov.
Weida TongNational Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Weida.Tong@fda.hhs.gov.
Huixiao HongNational Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Huixiao.Hong@fda.hhs.gov.
National Center for Toxicological Research · USUniversity of Arkansas at Fayetteville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer's disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus.

Indexed as

Androgen Receptor AntagonistsAndrogensAnimalsDiabetes MellitusEndocrine DisruptorsHumansReceptors, AndrogenAndrogen Receptor AntagonistsAndrogensEndocrine DisruptorsReceptors, Androgenandrogenic activity compoundsandrogen receptorcancerdiabetes mellitusmetabolic syndrome

Identifiers

PMID29295509
PMCPMC5800125
OpenAlexW2778789438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.