ArticleInternational journal of environmental research and public health2017
1950MHz Radio Frequency Electromagnetic Radiation Inhibits Testosterone Secretion of Mouse Leydig Cells.
Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Male cellular telephone exposure, fecundability, and semen quality: results from two preconception cohort studies.Human reproduction (Oxford, England) · 2021Pooled it
- The Effect of 2.45 GHz Radiofrequency Electromagnetic Radiation on Components of the Hypothalamic-Pituitary-Gonadal Axis in Male Rats.International journal of molecular sciences · 2026Article
- Differential metabolic responses of mouse Leydig and spermatogonia cells to radiofrequency electromagnetic field exposure.Frontiers in public health · 2025Article
- Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis.Histochemistry and cell biology · 2024Article
- Review
- Radio frequency electromagnetic radiations interfere with the Leydig cell functions in-vitro.PloS one · 2024Article
- Study of genotoxic and cytotoxic effects induced in human fibroblasts by exposure to pulsed and continuous 1.6 GHz radiofrequency.Frontiers in public health · 2024Article
- Review
- Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields.Environmental health : a global access science source · 2022Article
- Radiofrequency Electromagnetic Field Exposure and Apoptosis: A Scoping Review of In Vitro Studies on Mammalian Cells.International journal of molecular sciences · 2022Article
- Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction.Antioxidants (Basel, Switzerland) · 2021Review
- Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health.International journal of molecular sciences · 2021Review
- Effects of Long-Term Exposure to L-Band High-Power Microwave on the Brain Function of Male Mice.BioMed research international · 2021Article
- Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells.International journal of environmental research and public health · 2020Article
- TInternational journal of environmental research and public health · 2019Article
- Effects of 220 MHz Pulsed Modulated Radiofrequency Field on the Sperm Quality in Rats.International journal of environmental research and public health · 2019Article
- CeOInternational journal of nanomedicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More studies that are focused on the bioeffects of radio-frequency (RF) electromagnetic radiation that is generated from the communication devices, but there were few reports with confirmed results about the bioeffects of RF radiation on reproductive cells. To explore the effects of 1950 MHz RF electromagnetic radiation (EMR) on mouse Leydig (TM3) cells. TM3 cells were irradiated or sham-irradiated continuously for 24 h by the specific absorption rate (SAR) 3 W/kg radiation. At 0, 1, 2, 3, 4, and 5 days after irradiation, cell proliferation was detected by cell counting kit-8 (CCK-8) method, cell cycle distribution, percentage of apoptosis, and cellular reactive oxygen species (ROS) were examined by flow cytometry, Testosterone level was measured using enzyme-linked immunosorbent assay (ELISA) assay, messenger ribonucleic acid (mRNA) expression level of steroidogenic acute regulatory protein (StAR) and P450scc in TM3 cells was detected by real-time polymerase chain reaction (PCR). After being irradiated for 24 h, cell proliferation obviously decreased and cell cycle distribution, secretion capacity of Testosterone, and P450scc mRNA level were reduced. While cell apoptosis, ROS, and StAR mRNA level did not change significantly. The current results indicated that 24 h of exposure at 1950 MHz 3 W/kg radiation could cause some adverse effects on TM3 cells proliferation and Testosterone secretion, further studies about the biological effects in the reproductive system that are induced by RF radiation are also needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.