Evidence map›Paper›PMID 29295472›Full record

ArticleBrain sciences2017

A Prospective Birth Cohort Study on Maternal Cholesterol Levels and Offspring Attention Deficit Hyperactivity Disorder: New Insight on Sex Differences.

Yuelong Ji, Anne W Riley, Li-Ching Lee, Heather Volk, Xiumei Hong, Guoying Wang, Rayris Angomas, Tom Stivers, Anastacia Wahl, Hongkai Ji and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Association between infant feeding and ADHD development in childhood: a birth cohort study in Taiwan.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study.Autism research : official journal of the International Society for Autism Research · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Nightmares and Stress: A Longitudinal Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Yuelong JiCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. yji7@jhu.edu.
Anne W RileyCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. ariley1@jhu.edu.
Li-Ching LeeDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. hvolk1@jhu.edu.
Heather VolkWendy Klag Center for Autism and Developmental Disabilities & Department of Mental Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. xhong3@jhu.edu.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. gwang24@jhu.edu.
Rayris AngomasDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, 1 Boston Medical Center Place, Boston, MA 02118, USA. Rayris.Angomas@bmc.org.
Tom StiversDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, 1 Boston Medical Center Place, Boston, MA 02118, USA. Tom.Stivers@bmc.org.
Anastacia WahlDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, 1 Boston Medical Center Place, Boston, MA 02118, USA. awahl@bu.edu.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. hji@jhu.edu.
Tami R BartellStanley Manne Children's Research Institute, Mary Ann & J. Milburn Smith Child Health Research, Outreach and Advocacy Center, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Avenue, Chicago, IL 60611, USA. TBartell@luriechildrens.org.
Irina BurdIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 1800 Orleans St, Baltimore, MD 21287, USA. iburd@jhmi.edu.
David PaigeCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. dpaige@jhu.edu.
Margaret D FallinDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. dfallin@jhu.edu.
Barry ZuckermanDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, 1 Boston Medical Center Place, Boston, MA 02118, USA. barryzuckerman1@gmail.com.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. xwang82@jhu.edu.
Johns Hopkins University · USBoston Medical Center · USBoston University · USCenter for Autism and Related Disorders · USLurie Children's Hospital · US

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
NICHD NIH HHS R01 HD041702
6 · The paper itself

Abstract

Growing evidence suggests that maternal cholesterol levels are important in the offspring's brain growth and development. Previous studies on cholesterols and brain functions were mostly in adults. We sought to examine the prospective association between maternal cholesterol levels and the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. We analyzed data from the Boston Birth Cohort, enrolled at birth and followed from birth up to age 15 years. The final analyses included 1479 mother-infant pairs: 303 children with ADHD, and 1176 neurotypical children without clinician-diagnosed neurodevelopmental disorders. The median age of the first diagnosis of ADHD was seven years. The multiple logistic regression results showed that a low maternal high-density lipoprotein level (≤60 mg/dL) was associated with an increased risk of ADHD, compared to a higher maternal high-density lipoprotein level, after adjusting for pertinent covariables. A "J" shaped relationship was observed between triglycerides and ADHD risk. The associations with ADHD for maternal high-density lipoprotein and triglycerides were more pronounced among boys. The findings based on this predominantly urban low-income minority birth cohort raise a new mechanistic perspective for understanding the origins of ADHD and the gender differences and future targets in the prevention of ADHD.

Indexed as

ADHDhigh-density lipoproteinsex differencetriglyceride

Identifiers

PMID29295472
PMCPMC5789334
OpenAlexW2781015492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.