ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018
Diminished EEG habituation to novel events effectively classifies Parkinson's patients.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Auditory attention measured by EEG in neurological populations: systematic review of literature and meta-analysis.Scientific reports · 2023Pooled it
- Brain complexity represents uncertainty in sequence learning and corroborates habituation deficit in Parkinson disease patients.Scientific reports · 2025Article
- Independent component analysis of oddball EEG recordings to detect Parkinson's disease.Scientific reports · 2025Article
- Electrophysiological alterations during action semantic processing in Parkinson's disease.Neurobiology of aging · 2024Article
- Medication-invariant resting aperiodic and periodic neural activity in Parkinson's disease.Psychophysiology · 2024Article
- Parkinson's disease tremor prediction using EEG data analysis-A preliminary and feasibility study.BMC neurology · 2023Article
- Aberrations in temporal dynamics of cognitive processing induced by Parkinson's disease and Levodopa.Scientific reports · 2023Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Time-specific convergence and divergence in individual differences in behavior: Theory, protocols and analyzes.Ecology and evolution · 2023Review
- Stability, change, and reliable individual differences in electroencephalography measures: A lifespan perspective on progress and opportunities.NeuroImage · 2023Review
- Detection of Parkinson's disease from EEG signals using discrete wavelet transform, different entropy measures, and machine learning techniques.Scientific reports · 2022Article
- Novelty-induced frontal-STN networks in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Transfreq: A Python package for computing the theta-to-alpha transition frequency from resting state electroencephalographic data.Human brain mapping · 2022Article
- Parkinson's Disease Detection from Resting-State EEG Signals Using Common Spatial Pattern, Entropy, and Machine Learning Techniques.Diagnostics (Basel, Switzerland) · 2022Article
- Scalp recorded theta activity is modulated by reward, direction, and speed during virtual navigation in freely moving humans.Scientific reports · 2022Article
- Parkinson's disease is characterized by sub-second resting-state spatio-oscillatory patterns: A contribution from deep convolutional neural network.NeuroImage. Clinical · 2022Article
- The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease.International archives of otorhinolaryngology · 2022Review
- Evaluation of multi-feature auditory deviance detection in Parkinson's disease: a mismatch negativity study.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Linear predictive coding distinguishes spectral EEG features of Parkinson's disease.Parkinsonism & related disorders · 2020Article
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Authors and funding
5 authors.
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Abstract
objectivesWe aimed to test if EEG responses to novel events reliably dissociated individuals with Parkinson's disease and controls, and if this dissociation was sensitive and specific enough to be a candidate biomarker of cognitive dysfunction in Parkinson's disease.
methodsParticipants included N = 25 individuals with Parkinson's disease and an equal number of well-matched controls. EEG was recorded during a three-stimulus auditory oddball paradigm both ON and OFF medication.
resultsWhile control participants showed reliable EEG habituation to novel events over time, individuals with Parkinson's did not. In the OFF condition, individual differences in habituation correlated with years since diagnosis. Pattern classifiers achieved high sensitivity and specificity in discriminating patients from controls, with a maximum accuracy of 82%. Most importantly, the confidence of the classifier was related to years since diagnosis, and this correlation increased as the time course of differential habituation increasingly distinguished the groups.
conclusionsThese findings identify systemic alteration in an obligatory neural mechanism that may contribute to higher-level cognitive dysfunction in Parkinson's disease. SIGNIFICANCE: These findings suggest that EEG responses to novel events in this rapid, simple, and inexpensive test have tremendous promise for tracking individual trajectories of cognitive dysfunction in Parkinson's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.