ArticleLangenbeck's archives of surgery2018
Predictors of multiglandular disease in primary hyperparathyroidism.
Article in Langenbeck's archives of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05556499 (Interactions Between Bone and Parathyroid Tumors in Patiens With Primary Hyperparathyroidism), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interactions Between Bone and Parathyroid Tumors in Patiens With Primary Hyperparathyroidism (The PARABONE Study)
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- The relationship between postoperative parathormone suppression and surgical cure in primary hyperparathyroidism.Frontiers in endocrinology · 2025Article
- 24-hour Urine Calcium Predicts Reduced Fracture Incidence and Improved Bone Mineral Density After Surgery for Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2024Article
- Primary hyperparathyroidism: predictors of sporadic multi-gland disease.Endocrine connections · 2024Review
- Update on the current management of persistent and recurrent primary hyperparathyroidism after parathyroidectomy.World journal of clinical cases · 2023Review
- Osteocalcin modulates parathyroid cell function in human parathyroid tumors.Frontiers in endocrinology · 2023Article
- [Role of preoperative visualization in the choice of surgery for primary hyperparathyroidism].Problemy endokrinologii · 2022Article
- Immunohistochemical Profile of Parathyroid Tumours: A Comprehensive Review.International journal of molecular sciences · 2022Review
- Multiglandular Parathyroid Disease in Primary Hyperparathyroidism With Inconclusive Conventional Imaging.Physiological research · 2022Article
- Interpretation of intraoperative parathyroid hormone monitoring according to the Rome criterion in primary hyperparathyroidism.Scientific reports · 2022Article
- Management of primary and renal hyperparathyroidism: guidelines from the German Association of Endocrine Surgeons (CAEK).Langenbeck's archives of surgery · 2021Review
- Usefulness of the Wisconsin and CaPTHUS indices for predicting multiglandular disease in patients with primary hyperparathyroidism in a southern European population.Gland surgery · 2021Article
- Selection of parathyroidectomy methods for primary hyperparathyroidism according to concordance between ultrasonography and MIBI scan results.Gland surgery · 2021Article
- Changes in bone mineral density after parathyroidectomy in patients with moderate to severe primary hyperparathyroidism.The Journal of international medical research · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary hyperparathyroidism (pHPT) is caused by single- or multiglandular disease (MGD). Patients with MGD have an increased risk of complications at surgery and for persistence and recurrence after surgery. The study evaluated whether preoperative clinical and biochemical characteristics could predict MGD in patients with pHPT.
methodsWe retrospectively evaluated patients operated 1989-2013 for first-time, non-hereditary pHPT. MGD was defined in patients with more than one pathological gland excised at surgery or with persistent hypercalcemia after the excision of a single pathological parathyroid gland, confirmed by histopathology. Clinical and biochemical variables were compared in patients with single- and multiglandular disease. Logistic regression was used to identify variables predicting MGD, yielding odds ratios (OR) with 95% confidence intervals (CI).
resultsThere were 707 patients, of which 79 (11%) had MGD. Patients with MGD were more likely to have negative sestamibi scintigraphy than patients with single-gland disease, 15 of 49 (31%) vs. 70 of 402 (17%; p = 0.03), to suffer from diabetes (12 of 74, 16%) vs. 45 out of 626 patients (7.2%; p < 0.01) and had lower preoperative levels of urinary calcium (3.80 vs. 4.44 mmol/L; p = 0.04). Multivariable analysis identified negative scintigraphy (OR 2.42; 95% CI 1.18 to 4.79), diabetes (OR 2.75; 95% CI 1.31 to 4.97) and elevated levels of osteocalcin (OR 3.79, 95% CI: 1.75 to 8.21) as predictors of MGD.
conclusionNegative sestamibi scintigraphy, diabetes and elevated osteocalcin levels were predictors of MGD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.