ArticleThe Journal of clinical endocrinology and metabolism2018
Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.
Article in The Journal of clinical endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.The lancet. Diabetes & endocrinology · 2020Pooled it
- Maternal thyroid function and offspring birth anthropometrics in women with polycystic ovary syndrome.Frontiers in endocrinology · 2024Trial
- A comprehensive study on the association of personal air pollution exposure with thyroid hormones in pregnant women.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- The Relationship Between Thyroid Function or Subclinical Hypothyroidism in Early Pregnancy and Risk of Low Birth Weight and Small for Gestational Age of the Offspring: A Multicentre Prospective Cohort Study.International journal of medical sciences · 2026Article
- Physiological and Microbial Community Dynamics in Does During Mid-Gestation to Lactation and Their Impact on the Growth, Immune Function, and Microbiome Transmission of Offspring Kids.Animals : an open access journal from MDPI · 2025Article
- Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study.Environmental research · 2024Article
- Association between air pollutants, thyroid disorders, and thyroid hormone levels: a scoping review of epidemiological evidence.Frontiers in endocrinology · 2024Article
- [Association of maternal isolated thyroid peroxidase antibody positive in the first trimester with fetal growth].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Relationship between the Central and Peripheral Thyroid Sensitivity Indices and Fetal Macrosomia: A Cohort Study of Euthyroid Pregnant Women in China.Diagnostics (Basel, Switzerland) · 2023Article
- Effect of levothyroxine treatment on fetal growth among women with mild subclinical hypothyroidism and thyroid peroxidase antibody negative: a cohort study.BMC pregnancy and childbirth · 2023Article
- Maternal Thyroid Function and Birth Weight in Twins.Endocrinology · 2022Article
- Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes.Endocrine connections · 2022Article
- Could maternal thyroid function during pregnancy affect daughters' age at menarche through child growth? A mediation analysis.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Thyroxine Supplementation in Pregnant Women After Thyroidectomy for Thyroid Cancer and Neonatal Birth Weight.Frontiers in endocrinology · 2021Article
- [Thyroid disease in pregnancy : Review of current literature and guidelines].Wiener medizinische Wochenschrift (1946) · 2020Review
- Iodine Status, Thyroid Function, and Birthweight: A Complex Relationship in High-Risk Pregnancies.Journal of clinical medicine · 2020Article
- Effect of Gestational Weight Gain on Associations Between Maternal Thyroid Hormones and Birth Outcomes.Frontiers in endocrinology · 2020Article
- Association of vitamin A with gestational diabetes and thyroid disorders in pregnancy and their influence on maternal, fetal, and neonatal outcomes.Therapeutic advances in reproductive healthReview
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Context: Overt thyroid disease in pregnancy is a known risk factor for abnormal fetal growth and development. Data on the effects of milder forms of variation in maternal thyroid function on intrauterine growth are less well examined. Objective: We explored these associations using repeated thyroid hormone and ultrasound measurements. Design, Setting, and Participants: Data were obtained from 439 pregnant women without diagnosed thyroid disease who were participants in a case-control study of preterm birth nested within an ongoing prospective birth cohort in Boston, Massachusetts. Main Outcome Measures: Ultrasound and delivery indices of fetal growth were standardized to those measured in a larger population. Results: At median 10, 18, and 26 weeks of gestation, we observed significant inverse associations between free thyroxine (FT4) and birth weight z scores, with the strongest association detected at median 10 weeks, at which time a 10% increase in FT4 was associated with a 0.02 z score decrease (∼8.5 g) in birth weight (β = -0.41 for ln-transformed FT4; 95% confidence interval, -0.64 to -0.18). FT4 was also inversely associated with repeated measurements of estimated fetal weight, head circumference, and abdominal circumference. We observed weaker inverse associations for total T4 and a positive relationship between total triiodothyronine and birth weight z scores. We did not observe any associations for thyroid-stimulating hormone. Conclusion: In pregnant women without overt thyroid disease, subclinical changes in thyroid function parameters may influence fetal growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.