SynthesisEuropean heart journal. Cardiovascular Imaging2018
Quantitative myocardial perfusion evaluation with positron emission tomography and the risk of cardiovascular events in patients with coronary artery disease: a systematic review of prognostic studies.
Synthesis in European heart journal. Cardiovascular Imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Natural History of Myocardial αJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Trial
- Diagnosis of multivessel coronary artery disease usingJapanese journal of radiology · 2026Article
- Quantitative myocardial perfusion imaging across PET, SPECT, CMR, and CT.Frontiers in radiology · 2026Review
- Myocardial blood flow reference values for 13N-ammonia PET myocardial perfusion imaging in patients without flow-limiting coronary artery disease.European journal of nuclear medicine and molecular imaging · 2025Article
- Expanding interpretability through complexity reduction in machine learning-based modelling of cardiovascular disease: A myocardial perfusion imaging PET/CT prognostic study.European journal of clinical investigation · 2025Article
- Prognostic value of a novel artificial intelligence-based coronary computed tomography angiography-derived ischaemia algorithm for patients with suspected coronary artery disease.European heart journal. Cardiovascular Imaging · 2024Article
- Comparing various AI approaches to traditional quantitative assessment of the myocardial perfusion in [Scientific reports · 2024Article
- Significance of myocardial flow reserve after revascularization.European heart journal. Cardiovascular Imaging · 2023Article
- Prognostic Value of Modified Coronary Flow Capacity Derived From [Circulation. Cardiovascular imaging · 2023Article
- Comparison of the prognostic value of impaired stress myocardial blood flow, myocardial flow reserve, and myocardial flow capacity on low-dose Rubidium-82 SiPM PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- More evidence for prognostic value of quantification of myocardial perfusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Long-Term Prognostic Value ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Incremental prognostic value of positron emission tomography derived left ventricular mass.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- 2023 Guidelines of the Taiwan Society of Cardiology on the Diagnosis and Management of Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2023Article
- A Multimodality Myocardial Perfusion Phantom: Initial Quantitative Imaging Results.Bioengineering (Basel, Switzerland) · 2022Article
- Posttraumatic Stress Disorder, Myocardial Perfusion, and Myocardial Blood Flow: A Longitudinal Twin Study.Biological psychiatry · 2022Article
- Artificial Intelligence to Improve Risk Prediction with Nuclear Cardiac Studies.Current cardiology reports · 2022Review
- Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [European journal of nuclear medicine and molecular imaging · 2021Article
- Non-invasive Ischaemia Testing in Patients With Prior Coronary Artery Bypass Graft Surgery: Technical Challenges, Limitations, and Future Directions.Frontiers in cardiovascular medicine · 2021Review
- Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: AJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
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9 authors.
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Abstract
Aims: To evaluate the prognostic value of quantitative myocardial perfusion imaging with positron emission tomography (PET) for adverse cardiovascular outcomes in patients with known or suspected coronary artery disease (CAD). Methods and results: A search in MEDLINE and Embase was conducted for studies that evaluated (i) myocardial perfusion in absolute terms with PET, (ii) prognostic value for the development of major adverse cardiovascular events (MACE), cardiac death, and/or all-cause mortality, and (iii) patients with known or suspected CAD. Studies were divided according to the radiotracer utilized and their included population (patients with and without previous infarction). Comprehensive description and a selected instance of pooling were performed. Eight studies (n = 6804) were analysed and documented clear variability in population, quantitative PET variables operationalization [stress myocardial blood flow (sMBF) and flow reserve (MFR)], statistical covariate structure, follow-up, and radiotracer utilized. MFR was independently associated with MACE in eight studies [range of adjusted hazard ratios (HRs): 1.19-2.93]. The pooling instance demonstrated that MFR significantly associates with the development of MACEs (HR: 1.92 [1.29, 2.84]; P = 0.001). sMBF was only associated with MACE in two studies that evaluated it, and only one study documented sMBF as a better predictor than MFR. Conclusion: This systematic review demonstrates the prognostic value of quantitative myocardial perfusion evaluated with PET, in the form of MFR and sMBF, for the development of major adverse cardiovascular outcomes in populations with known or suspected CAD. In the qualitative comparison, MFR seems to outperform sMBF as an independent prognostic factor. Evidence is still lacking for assessing quantitative PET for the occurrence of cardiac death and all-cause mortality. There is clear heterogeneity in predictor operationalization and study performances.
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