SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Efficacy of Antitoxin Therapy in Treating Patients With Foodborne Botulism: A Systematic Review and Meta-analysis of Cases, 1923-2016.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Botulism in the 21st Century: A Scoping Review.The Brown journal of hospital medicine · 2023Pooled it
- Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- A case report of atypical type E botulism.World journal of emergency medicine · 2026Article
- Molecular Typing ofFoods (Basel, Switzerland) · 2025Article
- Chronic Botulism in Humans: A Case Series.Clinical case reports · 2025Article
- Cauda equina nerve root enhancement in adult intestinal toxemia botulism.BMC neurology · 2025Article
- Pattern and impact of antidotal administration in an Egyptian tertiary poison control center: A three-year retrospective study (2021-2023).Toxicology reports · 2025Article
- Comprehensive analysis of partial confounding clinical symptoms and treatment options of botulism: a case series.Frontiers in neurology · 2025Article
- Familial Cluster of Foodborne Botulism Associated with Homemade Dairy Products: A Case Series.International medical case reports journal · 2025Article
- Passive Immunisation in the Treatment of Infectious Diseases Related to Highly Potent Bacterial Toxins.Biomedicines · 2024Review
- Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies.ACS infectious diseases · 2024Article
- Iatrogenic botulism after intragastric botulinum neurotoxin injections - a major outbreak.Neurological research and practice · 2024Article
- Fecal Microbiota Transplantation for Severe Infant Botulism, China.Emerging infectious diseases · 2024Article
- From Beauty to Botulism: A Case Report Highlighting the Rare Risk of Botox Administration.Cureus · 2024Article
- An early scoring system to predict mechanical ventilation for botulism: a single-center-based study.World journal of emergency medicine · 2024Article
- New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A.BioImpacts : BI · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Tetanus toxin and botulinum neurotoxin-derived fusion molecules are effective bivalent vaccines.Applied microbiology and biotechnology · 2023Article
- A clinical approach to an unidentified aerosolized bioterrorism agent: a narrative review for emergency providers.Clinical and experimental emergency medicine · 2023Article
- Foodborne botulism and the importance of recognizing the disease in the emergency department: a case report.Journal of medical case reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Background: Botulism is a rare, potentially severe illness, often fatal if not appropriately treated. Data on treatment are sparse. We systematically evaluated the literature on botulinum antitoxin and other treatments. Methods: We conducted a systematic literature review of published articles in PubMed via Medline, Web of Science, Embase, Ovid, and Cumulative Index to Nursing and Allied Health Literature, and included all studies that reported on the clinical course and treatment for foodborne botulism. Articles were reviewed by 2 independent reviewers and independently abstracted for treatment type and toxin exposure. We conducted a meta-analysis on the effect of timing of antitoxin administration, antitoxin type, and toxin exposure type. Results: We identified 235 articles that met the inclusion criteria, published between 1923 and 2016. Study quality was variable. Few (27%) case series reported sufficient data for inclusion in meta-analysis. Reduced mortality was associated with any antitoxin treatment (odds ratio [OR], 0.16; 95% confidence interval [CI], .09-.30) and antitoxin treatment within 48 hours of illness onset (OR, 0.12; 95% CI, .03-.41). Data did not allow assessment of critical care impact, including ventilator support, on survival. Therapeutic agents other than antitoxin offered no clear benefit. Patient characteristics did not predict poor outcomes. We did not identify an interval beyond which antitoxin was not beneficial. Conclusions: Published studies on botulism treatment are relatively sparse and of low quality. Timely administration of antitoxin reduces mortality; despite appropriate treatment with antitoxin, some patients suffer respiratory failure. Prompt antitoxin administration and meticulous intensive care are essential for optimal outcome.
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Registered trials
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