Evidence map›Paper›PMID 29293902›Full record

ReviewCardiovascular research2018

Lineage tracking of origin and fate of smooth muscle cells in atherosclerosis.

Jacob F Bentzon, Mark W Majesky

Open access · bronzeAbstract readReview
In one paragraph

Review in Cardiovascular research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 88 citations in OpenAlex.

  1. Olfactomedin-2 at the Crossroads of Smooth Muscle Cell Plasticity.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  2. Adhesion of vessel wall to stentriever during combined technique for mechanical thrombectomy in acute ischemic stroke: A histomorphological study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  3. Review
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  9. Genetic silencing of KChannels (Austin, Tex.) · 2025
    Article
  10. Article
  11. Review
  12. Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  13. Article
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  15. Review
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  18. Article
  19. Pulmonary Vascular Remodeling in Pulmonary Hypertension.Journal of personalized medicine · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Jacob F BentzonCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Mark W MajeskyCenter for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Room 525, M/S C9S-5, Seattle, WA 98011, USA.
Aarhus University · DKUniversity of Washington · US

Funding

Reprogramming of mature smooth muscle cells to vascular progenitor cellsR01HL121877 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MARK W. MAJESKY, Mary CM Weiser-Evans · 2015 to 2026
$7.8M
Resident Progenitor Cells in the AdventitiaR01HL123650 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI MAJESKY, MARK W. · 2014 to 2017
$2.4M
NHLBI NIH HHS R01 HL121877NHLBI NIH HHS R01 HL123650
6 · The paper itself

Abstract

Advances in lineage-tracking techniques have provided new insights into the origins and fates of smooth muscle cells (SMCs) in atherosclerosis. Yet new tools present new challenges for data interpretation that require careful consideration of the strengths and weaknesses of the methods employed. At the same time, discoveries in other fields have introduced new perspectives on longstanding questions about steps in atherogenesis that remain poorly understood. In this article, we address both the challenges and opportunities for a better understanding of the mechanisms by which cells appearing as or deriving from SMCs accumulate in atherosclerosis.

Indexed as

Cell DifferentiationCell LineageActinsAnimalsAtherosclerosisBiomarkersGene Expression Regulation, DevelopmentalHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleNeovascularization, PhysiologicPhenotypeSignal TransductionActinsBiomarkers

Identifiers

PMID29293902
PMCPMC5852531
OpenAlexW2776384017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.