ArticlePLoS pathogens2018
Tomato leaf curl Yunnan virus-encoded C4 induces cell division through enhancing stability of Cyclin D 1.1 via impairing NbSKη -mediated phosphorylation in Nicotiana benthamiana.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 106 citations in OpenAlex.
- Characterization of the C4 protein encoded by parsley yellow leaf curl virus.Virology journal · 2026Article
- Tomato Yellow Leaf Curl Virus C4 Suppresses Antiviral Immunity by Targeting the 14-3-3 Protein SlTFT2.Molecular plant pathology · 2026Article
- Characterization of the C4 proteins encoded by okra-infecting geminiviruses in India.BMC plant biology · 2026Article
- A pathogen-induced translational shift enhances plant disease resistance without obvious fitness costs.aBIOTECH · 2026Article
- Defence-mediated phloem restriction of a plant virus facilitates insect transmission.Nature communications · 2025Article
- Geminiviral replication enhancer hijacks a negative regulator of cytokinin signaling to facilitate viral infection.Plant communications · 2025Article
- Characterisation of a Betasatellite Associated With Tomato Yellow Leaf Curl Guangdong Virus and Discovery of an Unusual Modulation of Virus Infection Associated With C4 Protein.Molecular plant pathology · 2025Article
- A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants.Nature communications · 2024Article
- V2 Protein Enhances the Replication of Genomic DNA of Mulberry Crinkle Leaf Virus.International journal of molecular sciences · 2024Article
- TaTHI2 interacts with CaPlant biotechnology journal · 2024Article
- Two genes encoded by mulberry crinkle leaf virus (MCLV): The V4 gene enhances viral replication, and the V5 gene is needed for MCLV infection in Nicotiana benthamiana.Virus research · 2024Article
- Broad functional landscape of geminivirus-encoded C4/AC4 protein.Crop health · 2023Review
- Unraveling the Mechanisms of Virus-Induced Symptom Development in Plants.Plants (Basel, Switzerland) · 2023Review
- Regulatory network of GSK3-like kinases and their role in plant stress response.Frontiers in plant science · 2023Review
- REPercussions: how geminiviruses recruit host factors for replication.Frontiers in microbiology · 2023Review
- Article
- GLRaV-2 protein p24 suppresses host defenses by interaction with a RAV transcription factor from grapevine.Plant physiology · 2022Article
- Molecular Traits and Functional Exploration ofInternational journal of molecular sciences · 2022Article
- Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana.PLoS pathogens · 2022Article
- Role of the Sw5 Gene Cluster in the Fight against Plant Viruses.Journal of virology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The whitefly-transmitted geminiviruses induce severe developmental abnormalities in plants. Geminivirus-encoded C4 protein functions as one of viral symptom determinants that could induce abnormal cell division. However, the molecular mechanism by which C4 contributes to cell division induction remains unclear. Here we report that tomato leaf curl Yunnan virus (TLCYnV) C4 interacts with a glycogen synthase kinase 3 (GSK3)/SHAGGY-like kinase, designed NbSKη, in Nicotiana benthamiana. Pro32, Asn34 and Thr35 of TLCYnV C4 are critical for its interaction with NbSKη and required for C4-induced typical symptoms. Interestingly, TLCYnV C4 directs NbSKη to the membrane and reduces the nuclear-accumulation of NbSKη. The relocalization of NbSKη impairs phosphorylation dependent degradation on its substrate-Cyclin D1.1 (NbCycD1;1), thereby increasing the accumulation level of NbCycD1;1 and inducing the cell division. Moreover, NbSKη-RNAi, 35S::NbCycD1;1 transgenic N. benthamiana plants have the similar phenotype as 35S::C4 transgenic N. benthamiana plants on callus-like tissue formation resulted from abnormal cell division induction. Thus, this study provides new insights into mechanism of how a viral protein hijacks NbSKη to induce abnormal cell division in plants.
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