ArticlePLoS pathogens2018
Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC3000.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
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Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 183 citations in OpenAlex.
- Tryptophan metabolism and plant health: mechanisms of action and application prospects.Frontiers in plant science · 2026Pooled it
- Rhizophagus irregularis modulates neighbour-primed defences in Medicago truncatula against foliar pathogens via common mycelial network-mediated inter-plant signals.Communications biology · 2026Article
- Auxin (Indole-3-acetic acid) modulation of quorum sensing enhances phage susceptibility in Klebsiella pneumoniae.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- NIT24 and NIT29-Dependent Auxin Biosynthesis Promotes Virulence and Auxin-SA Antagonism in Rice During Xanthomonas oryzae pv. oryzae Infection.The plant pathology journal · 2026Article
- Genomic and Functional Analysis of Two Halophilic IAA-Producing Vreelandella Strains.Current microbiology · 2026Article
- Auxin dysregulation: a key early event in sugarcane susceptibility to Sporisorium scitamineum.BMC plant biology · 2026Article
- A multi-omics approach reveals that the plant-parasitic nematodeParasitology · 2026Article
- A voyage of reprogrammable metabolic bioengineering reshapes plant defense: from editing tools to synthetic systems.Frontiers in plant science · 2026Review
- Article
- Three plant growth-promoting rhizobacteria from the Qinghai-Tibet Plateau enhanced plant growth and alleviated low-temperature and drought stress.Frontiers in plant science · 2026Article
- Influence of Tryptophan Metabolism on the Protective Effect of Weissella paramesenteroides WpK4 in a Murine Model of Chemotherapy-Induced Intestinal Mucositis.Probiotics and antimicrobial proteins · 2025Article
- Salmonella enterica exploits the auxin signaling pathway to overcome stomatal immunity.PLoS pathogens · 2025Article
- A putative auxin efflux carrier FgAec1 contributes to the pathogenicity of Fusarium graminearum.BMC biology · 2025Article
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- Article
- NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol.Nature communications · 2025Article
- Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense.Science advances · 2025Article
- The structural basis for the broad aldehyde specificity of the aminoaldehyde dehydrogenase PauC from the human pathogen Pseudomonas aeruginosa.Protein science : a publication of the Protein Society · 2025Article
- Pseudomonas Species Isolated From Lotus Nodules Are Genetically Diverse and Promote Plant Growth.Environmental microbiology · 2025Article
- Puccinia striiformis Effector PNPi Suppresses TaIAA14 Expression to Inhibit Host Cell Death Response.Molecular plant pathology · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial pathogen Pseudomonas syringae modulates plant hormone signaling to promote infection and disease development. P. syringae uses several strategies to manipulate auxin physiology in Arabidopsis thaliana to promote pathogenesis, including its synthesis of indole-3-acetic acid (IAA), the predominant form of auxin in plants, and production of virulence factors that alter auxin responses in the host; however, the role of pathogen-derived auxin in P. syringae pathogenesis is not well understood. Here we demonstrate that P. syringae strain DC3000 produces IAA via a previously uncharacterized pathway and identify a novel indole-3-acetaldehyde dehydrogenase, AldA, that functions in IAA biosynthesis by catalyzing the NAD-dependent formation of IAA from indole-3-acetaldehyde (IAAld). Biochemical analysis and solving of the 1.9 Å resolution x-ray crystal structure reveal key features of AldA for IAA synthesis, including the molecular basis of substrate specificity. Disruption of aldA and a close homolog, aldB, lead to reduced IAA production in culture and reduced virulence on A. thaliana. We use these mutants to explore the mechanism by which pathogen-derived auxin contributes to virulence and show that IAA produced by DC3000 suppresses salicylic acid-mediated defenses in A. thaliana. Thus, auxin is a DC3000 virulence factor that promotes pathogenicity by suppressing host defenses.
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