ArticlePloS one2018
Computer-analyzed facial expression as a surrogate marker for autism spectrum social core symptoms.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- New Technologies as Promising Tools for Assessing Facial Emotion Expressions Impairments in ASD: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms.Molecular autism · 2021Trial
- Facial expressions and emotional experience during social interaction in autism and schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Multi-View Analysis of Facial Expressions in Minimally Verbal Autism: Preliminary Evidence From Social Communication Observations.Journal of autism and developmental disorders · 2026Article
- Comparing three algorithms of automated facial expression analysis in autistic children: different sensitivities but consistent proportions.Molecular autism · 2025Article
- Exploring emotion recognition in patients with mild cognitive impairment and Alzheimer's dementia undergoing a rehabilitation programPloS one · 2025Article
- Commercial Wearables for the Management of People with Autism Spectrum Disorder: A Review.Biosensors · 2024Review
- Positive Emotional Responses to Socially Assistive Robots in People With Dementia: Pilot Study.JMIR aging · 2024Article
- The cross-race effect in automatic facial expression recognition violates measurement invariance.Frontiers in psychology · 2023Article
- Effects of temporal properties of facial expressions on the perceived intensity of emotion.Royal Society open science · 2023Article
- Alterations in facial expressions of emotion: Determining the promise of ultrathin slicing approaches and comparing human and automated coding methods in psychosis risk.Emotion (Washington, D.C.) · 2022Article
- The Current View on the Paradox of Pain in Autism Spectrum Disorders.Frontiers in psychiatry · 2022Review
- Digital Behavioral Phenotyping Detects Atypical Pattern of Facial Expression in Toddlers with Autism.Autism research : official journal of the International Society for Autism Research · 2021Article
- Proof of Concept: A Brief Psycho-Educational Training Program to Increase the Use of Positive Emotion Regulation Strategies in Individuals With Autism Spectrum Disorder.Frontiers in psychology · 2021Article
- Data-Driven Diagnostics and the Potential of Mobile Artificial Intelligence for Digital Therapeutic Phenotyping in Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
- Towards the automatic detection of social biomarkers in autism spectrum disorder: introducing the simulated interaction task (SIT).NPJ digital medicine · 2020Article
- Children with autism spectrum disorder produce more ambiguous and less socially meaningful facial expressions: an experimental study using random forest classifiers.Molecular autism · 2020Article
- Alterations in facial expressivity in youth at clinical high-risk for psychosis.Journal of abnormal psychology · 2019Article
- Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder.PloS one · 2019Article
- Oral-Motor and Lexical Diversity During Naturalistic Conversations in Adults with Autism Spectrum Disorder.Proceedings of the conference. Association for Computational Linguistics. North American Chapter. Meeting · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop novel interventions for autism spectrum disorder (ASD) core symptoms, valid, reliable, and sensitive longitudinal outcome measures are required for detecting symptom change over time. Here, we tested whether a computerized analysis of quantitative facial expression measures could act as a marker for core ASD social symptoms. Facial expression intensity values during a semi-structured socially interactive situation extracted from the Autism Diagnostic Observation Schedule (ADOS) were quantified by dedicated software in 18 high-functioning adult males with ASD. Controls were 17 age-, gender-, parental socioeconomic background-, and intellectual level-matched typically developing (TD) individuals. Statistical analyses determined whether values representing the strength and variability of each facial expression element differed significantly between the ASD and TD groups and whether they correlated with ADOS reciprocal social interaction scores. Compared with the TD controls, facial expressions in the ASD group appeared more "Neutral" (d = 1.02, P = 0.005, PFDR < 0.05) with less variation in Neutral expression (d = 1.08, P = 0.003, PFDR < 0.05). Their expressions were also less "Happy" (d = -0.78, P = 0.038, PFDR > 0.05) with lower variability in Happy expression (d = 1.10, P = 0.003, PFDR < 0.05). Moreover, the stronger Neutral facial expressions in the ASD participants were positively correlated with poorer ADOS reciprocal social interaction scores (ρ = 0.48, P = 0.042). These findings indicate that our method for quantitatively measuring reduced facial expressivity during social interactions can be a promising marker for core ASD social symptoms.
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