ArticlePloS one2018
FLP-1 neuropeptides modulate sensory and motor circuits in the nematode Caenorhabditis elegans.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.Nature communications · 2026Article
- Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans.Biology open · 2026Article
- Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor.bioRxiv : the preprint server for biology · 2025Article
- Food sensing controlsScience advances · 2025Article
- Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.Nature communications · 2024Article
- Mapping lineage-traced cells across time points with moslin.Genome biology · 2024Article
- Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance.Cell reports · 2024Article
- Indirect Modulation by FLP-1 Peptides on Chemotaxis and Dispersal Behavior inmicroPublication biology · 2023Article
- G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans.PLoS genetics · 2023Article
- Positive interaction between ASH and ASK sensory neurons accelerates nociception and inhibits behavioral adaptation.iScience · 2022Article
- Sexual morph specialisation in a trioecious nematode balances opposing selective forces.Scientific reports · 2022Article
- A role for the Erk MAPK pathway in modulating SAX-7/L1CAM-dependent locomotion in Caenorhabditis elegans.Genetics · 2022Article
- Background mutation in strain RB2126 affects the locomotion behavior ofmicroPublication biology · 2021Article
- Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.Nature communications · 2021Article
- Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.Frontiers in molecular neuroscience · 2021Review
- Behavioral States.Genetics · 2020Review
- A Chemosensory GPCR as a Potential Target to Control the Root-Knot NematodeMolecules (Basel, Switzerland) · 2019Article
- Impacts of Root Metabolites on Soil Nematodes.Frontiers in plant science · 2019Review
- Signatures of proprioceptive control inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Neuropeptides encoded byPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Parasitic nematodes infect over one quarter of the population worldwide, causing morbidity in over one billion people. Current anthelmintic drugs are beginning to lose effectiveness due to the presence of resistant strains. We are interested in the role of neuropeptides, which regulate behaviors in all organisms, as another possible target for anthelmintic drugs. FMRFamide-related peptides (FaRPs) are a family of neuropeptides that are conserved throughout the animal kingdom. In particular, nematodes contain the largest family of FaRPs identified thus far and many of these FaRPs are identical among different nematode species; FaRPs in nematodes are collectively referred to as FLPs (FMRFamide-like peptides). However, little is known about the function of these FLPs. We are using the non-parasitic nematode Caenorhabditis elegans as a model for examining FLPs in nematodes. C. elegans contains at least 31 flp genes that encode 72 potential FLPs. Among the flp genes, flp-1 is one of the few that is universally found in nematodes. FLP-1 neuropeptides were previously reported to be involved in sensory and motor functions. However, previous alleles of flp-1 also disrupted a neighboring gene, daf-10. To understand the phenotypes of flp-1, new alleles that specifically disrupt flp-1 were characterized. The previously reported locomotory and egg-laying defects were found to be due to loss of flp-1, while the osmolarity defect is due to loss of daf-10. In addition, loss of flp-1 and daf-10 both cause several phenotypes that increase in severity in the double mutants by disrupting different neurons in the neural circuits.
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