Evidence map›Paper›PMID 29292845›Full record

ArticleJournal of biophotonics2018

Evaluating the effects of maternal alcohol consumption on murine fetal brain vasculature using optical coherence tomography.

Raksha Raghunathan, Chen Wu, Manmohan Singh, Chih-Hao Liu, Rajesh C Miranda, Kirill V Larin

Abstract read
In one paragraph

Article in Journal of biophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Mouse embryo phenotyping with optical coherence tomography.Frontiers in cell and developmental biology · 2022
    Review
  12. Article
  13. Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Fetal regional brain protein signature in FASD rat model.Reproductive toxicology (Elmsford, N.Y.) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Raksha RaghunathanDepartment of Biomedical Engineering, University of Houston, Houston, Texas.
Chen WuDepartment of Biomedical Engineering, University of Houston, Houston, Texas.
Manmohan SinghDepartment of Biomedical Engineering, University of Houston, Houston, Texas.
Chih-Hao LiuDepartment of Biomedical Engineering, University of Houston, Houston, Texas.
Rajesh C MirandaDepartment of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, College of Medicine, College Station, Texas.
Kirill V LarinDepartment of Biomedical Engineering, University of Houston, Houston, Texas.
University of Houston · USTexas A&M Health Science Center · US

Funding

Optical Coherence Tomography to Study Effect of Poly - Drug Exposure on Fetal Brain DevelopmentR01HD086765 · NICHD · UNIVERSITY OF HOUSTON · PI Kirill V Larin, Irina Larina · 2016 to 2026
$5.0M
Biomechanics of early mammalian cardiogenesisR01HL120140 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARINA, IRINA · 2013 to 2017
$2.0M
NHLBI NIH HHS R01 HL120140NICHD NIH HHS R01 HD086765
6 · The paper itself

Abstract

Prenatal alcohol exposure (PAE) can result in a range of anomalies including brain and behavioral dysfunctions, collectively termed fetal alcohol spectrum disorder. PAE during the 1st and 2nd trimester is common, and research in animal models has documented significant neural developmental deficits associated with PAE during this period. However, little is known about the immediate effects of PAE on fetal brain vasculature. In this study, we used in utero speckle variance optical coherence tomography, a high spatial- and temporal-resolution imaging modality, to evaluate dynamic changes in microvasculature of the 2nd trimester equivalent murine fetal brain, minutes after binge-like maternal alcohol exposure. Acute binge-like PAE resulted in a rapid (<1 hour) and significant decrease (P < .001) in vessel diameter as compared to the sham group. The data show that a single binge-like maternal alcohol exposure resulted in swift vasoconstriction in fetal brain vessels during the critical period of neurogenesis.

Indexed as

Tomography, Optical CoherenceAlcohol DrinkingAnimalsBlood VesselsBrainFemaleFetusMiceNeovascularization, PhysiologicPregnancyTime Factorsbrain vasculaturefetal alcohol spectrum disordermurine fetusoptical coherence tomographyprenatal alcohol exposure

Identifiers

PMID29292845
PMCPMC6292438
OpenAlexW2782215234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.