Evidence map›Paper›PMID 29292750›Full record

ReviewInternational journal of molecular sciences2017

LncRNA Structural Characteristics in Epigenetic Regulation.

Chenguang Wang, Lianzong Wang, Yu Ding, Xiaoyan Lu, Guosi Zhang, Jiaxin Yang, Hewei Zheng, Hong Wang, Yongshuai Jiang, Liangde Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenguang WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wangcg@hrbmu.edu.cn.
Lianzong WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wanglz@hrbmu.edu.cn.
Yu DingCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. dingyu@hrbmu.edu.cn.
Xiaoyan LuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. luxy@hrbmu.edu.cn.
Guosi ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. zhanggs@hrbmu.edu.cn.
Jiaxin YangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. yangjx@hrbmu.edu.cn.
Hewei ZhengCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. zhenghw@hrbmu.edu.cn.
Hong WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wanghong84@ems.hrbmu.edu.cn.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. jiangyongshuai@ems.hrbmu.edu.cn.
Liangde XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. xuliangde@hrbmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been shown to play important epigenetic regulatory roles in key molecular processes, such as gene expression, genetic imprinting, histone modification, chromatin dynamics, and other activities by forming specific structures and interacting with all kinds of molecules. This paper mainly discusses the correlation between the structure and function of lncRNAs with the recent progress in epigenetic regulation, which is important to the understanding of the mechanism of lncRNAs in physiological and pathological processes.

Indexed as

Genomic ImprintingAnimalsChromatinChromatin Assembly and DisassemblyEpigenesis, GeneticHumansRNA, Long NoncodingChromatinRNA, Long Noncodingepigenetic regulationlncRNA structureregulation protein recruitRNA-protein binding motif

Identifiers

PMID29292750
PMCPMC5751261

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.