ArticleJournal of magnetic resonance imaging : JMRI2018
Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: A 4-year longitudinal study.
Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The trial behind it
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Who cites it
63 citing papers in PubMed, 97 citations in OpenAlex.
- The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial.JMIR research protocols · 2025Trial
- Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.Journal of Alzheimer's disease : JAD · 2020Trial
- The effect of physical exercise on cerebral blood flow in Alzheimer's disease.NeuroImage. Clinical · 2018Trial
- Neurovascular-metabolic coupling links hearing loss to cognitive impairment: Evidence from GABA and cerebral blood flow in presbycusis.Neurobiology of disease · 2026Article
- Inter-Shot Motion Correction of Segmented 3D-GRASE ASL Perfusion Imaging With Self-Navigation and CAIPI.Magnetic resonance in medicine · 2026Article
- Relationships between cerebral blood flow and cognition in young adults born very preterm and at term.Scientific reports · 2026Article
- Cerebral oxygen extraction and blood flow in community-based older adults: associations with white matter hyperintensity and neurocognitive function.Brain communications · 2026Article
- A CSF Background Suppression Scheme in Arterial Spin Labeling MRI.NMR in biomedicine · 2026Article
- Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan.PLoS biology · 2025Article
- Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults.NeuroImage · 2025Article
- The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Narrowings of the Deep Cerebral Perforating Arteries Ostia: Geometry, Structure, and Clinical Implications.Journal of stroke · 2025Article
- Advantages and challenges of using arterial spin labelling MRI to monitor cerebral blood flow in multi-centre clinical trials of neurodegenerative disease: Experience from the RADAR study.Cerebral circulation - cognition and behavior · 2025Article
- Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry.Aging medicine (Milton (N.S.W)) · 2024Article
- Article
- Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury.BMC neurology · 2024Article
- Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review.Aging and disease · 2024Review
- Article
- Effects of Brain Maintenance and Cognitive Reserve on Age-Related Decline in Three Cognitive Abilities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundWith the disappointing outcomes of clinical trials on patients with Alzheimer's disease or mild cognitive impairment (MCI), there is increasing attention to understanding cognitive decline in normal elderly individuals, with the goal of identifying subjects who are most susceptible to imminent cognitive impairment. PURPOSE/HYPOTHESIS: To evaluate the potential of cerebral blood flow (CBF) as a biomarker by investigating the relationship between CBF at baseline and cognition at follow-up. STUDY TYPE: Prospective longitudinal study with a 4-year time interval. POPULATION: 309 healthy subjects aged 20-89 years old. FIELD STRENGTH/SEQUENCE: 3T pseudo-continuous-arterial-spin-labeling MRI. ASSESSMENT: CBF at baseline and cognitive assessment at both baseline and follow-up. STATISTICAL TESTS: Linear regression analyses with age, systolic blood pressure, physical activity, and baseline cognition as covariates.
resultsLinear regression analyses revealed that whole-brain CBF at baseline was predictive of general fluid cognition at follow-up. This effect was observed in the older group (age ≥54 years, β = 0.221, P = 0.004), but not in younger or entire sample (β = 0.018, P = 0.867 and β = 0.089, P = 0.098, respectively). Among major brain lobes, frontal CBF had the highest sensitivity in predicting future cognition, with a significant effect observed for fluid cognition (β = 0.244 P = 0.001), episodic memory (β = 0.294, P = 0.001), and reasoning (β = 0.186, P = 0.027). These associations remained significant after accounting for baseline cognition. Voxelwise analysis revealed that medial frontal cortex and anterior cingulate cortex, part of the default mode network (DMN), are among the most important regions in predicting fluid cognition. DATA
conclusionIn a healthy aging cohort, CBF can predict general cognitive ability as well as specific domains of cognitive function. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2018;48:449-458.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.