Evidence map›Paper›PMID 29292399›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2017

Plasma Metabolomics Analysis Based on GC-MS in Infertile Males with Kidney-Yang Deficiency Syndrome.

Piao Zheng, Yun Wang, Hongmei Lu, Xinyi Zhou, Tao Tang, Rong Fan, Chunhu Zhang, Hanjin Cui, Yang Wang, Jiekun Luo

Open access · hybridAbstract read
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In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Piao ZhengDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.ORCID 0000-0003-3649-8181
Yun WangDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.
Hongmei LuCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410008, China.
Xinyi ZhouCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410008, China.
Tao TangDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.
Rong FanDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.
Chunhu ZhangDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.ORCID 0000-0001-8829-3319
Hanjin CuiDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.
Yang WangDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.ORCID 0000-0002-1225-6017
Jiekun LuoDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410083, China.ORCID 0000-0002-9622-533X
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChinese medicine syndrome diagnosis is the key requisite in the treatment of male infertility with traditional Chinese medicine (TCM). Kidney-Yang deficiency syndrome (KYDS) is the critical Chinese medicine syndrome of male infertility. To explore the modernized mechanisms of KYDS in male infertility, this study aims to investigate the metabolomics of males with KYDS.

methodsThe gas chromatography-mass spectrometry method was applied to analyze the plasma samples of 67 infertile males with KYDS compared with 55 age-matched healthy controls. The chemometric methods including principal component and partial least squares-discriminate analyses were employed to identify the potential biochemical patterns. With the help of the variable importance for the projection and receiver operating characteristic curve analyses, the potential biomarkers were extracted to define the clinical utility. Simultaneously the high-quality KEGG metabolic pathways database was used to identify the related metabolic pathways.

resultsThe metabolomics profiles of infertile males with KYDS including 10 potential biomarkers and six metabolic pathways were identified. They precisely distinguished infertile males with KYDS from healthy controls.

conclusionsThese potential biomarkers and pathways suggest the substantial basis of infertile males with KYDS. The metabolomics profiles highlight the modernized mechanisms of infertile males with KYDS.

Identifiers

PMID29292399
PMCPMC5674502
OpenAlexW2756990390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.