ArticleEvidence-based complementary and alternative medicine : eCAM2017
Optimization of Phenolic Compounds Extraction from Flax Shives and Their Effect on Human Fibroblasts.
Article in Evidence-based complementary and alternative medicine : eCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Constitutive Expression of AtVTE2 in Flax Is Associated with Changes in Isoprenoid Metabolism and Stem Cell-Wall Composition.International journal of molecular sciences · 2026Article
- Photoprotective Effect ofMolecules (Basel, Switzerland) · 2025Article
- Bioactive Potential of a Grape Stem Blend: A Sustainable Approach to Skin Regeneration.Antioxidants (Basel, Switzerland) · 2025Article
- Endophytic non-pathogenicFrontiers in plant science · 2024Article
- Metabolic bioprofiling of different Glycyrrhiza glabra solvent fractions for the identification of anti-adenoviral compounds using LC-HRMS/MS and in-vitro cytopathic assay coupled with chemometry.BMC complementary medicine and therapies · 2023Article
- The Technological Process of Obtaining New Linen Dressings Did Not Cause the Loss of Their Wound-Healing Properties.Materials (Basel, Switzerland) · 2021Article
- Wound coverage by the linen dressing accelerates ulcer healing.Postepy dermatologii i alergologii · 2021Article
- Were our Ancestors Right in Using Flax Dressings? Research on the Properties of Flax Fibre and Its Usefulness in Wound Healing.Oxidative medicine and cellular longevity · 2020Article
- Enzymatic treatment of flax for use in composites.Biotechnology reports (Amsterdam, Netherlands) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to evaluate the most effective technique for extraction of phenolics present in flax shives and to assess their effect on human fibroblasts. Flax shives are by-products of fibre separation, but they were found to be a rich source of phenolic compounds and thus might have application potential. It was found that the optimal procedure for extraction of phenolics was hydrolysis enhanced by the ultrasound with NaOH for 24 h at 65°C and subsequent extraction with ethyl acetate. The influence of the flax shives extract on fibroblast growth and viability was assessed using the MTT and SRB tests. Moreover, the influence of flax shives extract on the extracellular matrix remodelling process was verified. The 20% increase of the viability was observed upon flax shives extract treatment and the decrease of mRNA collagen genes, an increase of matrix metalloproteinase gene expression, and reduction in levels of interleukin 6, interleukin 10, and suppressor of cytokinin signaling 1 mRNA were observed. Alterations in MCP-1 mRNA levels were dependent on flax shives extract concentration. Thus, we suggested the possible application of flax shives extract in the wound healing process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.