Evidence map›Paper›PMID 29292384›Full record

ArticleNature microbiology2018

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

Jia Chen, Karthik Sathiyamoorthy, Xianming Zhang, Samantha Schaller, Bethany E Perez White, Theodore S Jardetzky, Richard Longnecker

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.

  1. Pooled it
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  15. Association of Single-Nucleotide Polymorphisms onInternational journal of molecular sciences · 2025
    Article
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  19. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  20. Article

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jia ChenDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Karthik SathiyamoorthyDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5736-8709
Xianming ZhangDepartment of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Samantha SchallerDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Bethany E Perez WhiteDepartment of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-5594-0599
Theodore S JardetzkyDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Richard LongneckerDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. r-longnecker@northwestern.edu.ORCID http://orcid.org/0000-0001-7175-6217
Northwestern University · USStanford University · USUniversity of Illinois Chicago · US

Funding

Structural and Functional Studies of gp42 and HLA Class II in EBV EntryR01AI076183 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JARDETZKY, THEODORE S, LONGNECKER, RICHARD M · 2008 to 2017
$4.6M
Inhibitors of the Epstein-Barr Virus Entry MachineryR01CA117794 · NCI · STANFORD UNIVERSITY · PI JARDETZKY, THEODORE S, LONGNECKER, RICHARD M · 2006 to 2016
$3.0M
Structure and function of EBV protein complexes that trigger epithelial cell entryR21AI119480 · NIAID · STANFORD UNIVERSITY · PI JARDETZKY, THEODORE S, LONGNECKER, RICHARD M · 2015 to 2016
$460k
NCI NIH HHS R01 CA117794NIAID NIH HHS R01 AI076183NIAID NIH HHS R21 AI119480
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is an oncogenic virus that infects more than 90% of the world's population

Indexed as

Virus InternalizationAnimalsAntigens, NeoplasmB-LymphocytesCell FusionCHO CellsCricetulusEphrin-A2Epithelial CellsGene Knockout TechniquesHEK293 CellsHerpesvirus 4, HumanHumansIntegrinsReceptor, EphA2Receptor, EphA4Antigens, NeoplasmEPHA2 protein, humanEphrin-A2integrin alphaVbeta5integrin alphavbeta6integrin alphavbeta8IntegrinsReceptor, EphA2Receptor, EphA4Receptors, VitronectinRNA, Small Interfering

Identifiers

PMID29292384
PMCPMC5972547
OpenAlexW2780449395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.