ArticleNature neuroscience2018
Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06986122 (Controllability of Virtual Contexts for the Modulation of the Affective Experience), which is not on this map. Cited by 138 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Controllability of Virtual Contexts for the Modulation of the Affective Experience
Who cites it
138 citing papers in PubMed, 2 syntheses or guidelines pooled it, 293 citations in OpenAlex.
- Social exclusion reliably engages the default network: A meta-analysis of Cyberball.NeuroImage · 2021Pooled it
- Meta-analytic evidence for a joint neural mechanism underlying response inhibition and state anger.Human brain mapping · 2020Pooled it
- A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation.Molecular psychiatry · 2025Trial
- Effects of compassion training on brain responses to suffering others.Social cognitive and affective neuroscience · 2021Trial
- Beyond Sharing Unpleasant Affect-Evidence for Pain-Specific Opioidergic Modulation of Empathy for Pain.Cerebral cortex (New York, N.Y. : 1991) · 2021Trial
- Trial
- Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression.Human brain mapping · 2020Trial
- Early risk factors and six month posttraumatic stress disorder symptom severity following trauma.European journal of psychotraumatology · 2026Article
- Midfrontal theta power relates to response speeding following frustrative nonreward.NeuroImage · 2026Article
- Human ticklishness is a widespread, culturally shared and bodily organized sensory experience.Nature human behaviour · 2026Article
- The Effect of Psychological State on Pain Perception in a Simulated Dental Setting Among Young Adults: A Randomized Comparative Experiment.Dentistry journal · 2026Article
- Altered locus coeruleus functional connectivity in migraine without aura based on resting-state functional magnetic resonance imaging.Journal of oral & facial pain and headache · 2026Article
- Temporal Transcriptomic Changes in the Cingulate Cortex of Neuropathic Pain Mice.Biomedicines · 2026Article
- Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026Article
- Neural Representations and Functional Connections Underlie Subjective Positive Affect.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- Temporoparietal Junction Selectively Mediates Social Projection in Mentalizing.Neuroscience bulletin · 2026Article
- Activation in the right orbitofrontal cortex during pain processing as a transdiagnostic neural representation in suicide attempters.Brain imaging and behavior · 2026Article
- Decoding P300 as a shared neural mechanism for oddball target detection and working memory updating.iScience · 2026Article
- Brain-immune correlates of quality of life in adolescents with chronic musculoskeletal pain.Brain, behavior, and immunity · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 6 countries.
Funding
Abstract
The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.