ArticleBehavioural brain research2018
Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress.
Article in Behavioural brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Connectivity patterns in the DMN that are impacted by traumatic stress.Research square · 2026Article
- The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders.Molecular psychiatry · 2026Review
- Sexually dimorphic effects of single prolonged stress on conditioned suppression behavior in Long Evans rats with no detection of altered mRNA expression of VGLUT1, GAD1, and Arc in the ventral hippocampus.Frontiers in behavioral neuroscience · 2026Article
- Basal forebrain cholinergic systems as circuits through which traumatic stress disrupts emotional memory regulation.Neuroscience and biobehavioral reviews · 2024Review
- The role of avoidance in modulating single prolonged stress effects on emotional memory in male and female rats.Behavioural brain research · 2023Article
- The role of estrogen receptor manipulation during traumatic stress on changes in emotional memory induced by traumatic stress.Psychopharmacology · 2023Article
- The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder.Frontiers in neuroscience · 2023Review
- Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits.International journal of molecular sciences · 2022Review
- Fear learning-induced changes in AMPAR and NMDAR expression in the fear circuit.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- PI3K-Akt Signaling in the Basolateral Amygdala Facilitates Traumatic Stress Enhancements in Fear Memory.The international journal of neuropsychopharmacology · 2021Article
- Emotional remodeling with oxytocin durably rescues trauma-induced behavioral and neuro-morphological changes in rats: a promising treatment for PTSD.Translational psychiatry · 2020Article
- Effects of stress on the structure and function of the medial prefrontal cortex: Insights from animal models.International review of neurobiology · 2020Review
- Single prolonged stress alters neural activation in the periacqueductal gray and midline thalamic nuclei during emotional learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain.Journal of visualized experiments : JoVE · 2019Article
- Rodent models of impaired fear extinction.Psychopharmacology · 2019Review
- Preclinical studies of stress, extinction, and prefrontal cortex: intriguing leads and pressing questions.Psychopharmacology · 2019Review
- Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala.Frontiers in neuroscience · 2018Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
Neural circuits via which stress leads to disruptions in fear extinction is often explored in animal stress models. Using the single prolonged stress (SPS) model of post traumatic stress disorder and the immediate early gene (IEG) c-Fos as a measure of neural activity, we previously identified patterns of neural activity through which SPS disrupts extinction retention. However, none of these stress effects were specific to fear or extinction learning and memory. C-Jun is another IEG that is sometimes regulated in a different manner to c-Fos and could be used to identify emotional learning/memory specific patterns of neural activity that are sensitive to SPS. Animals were either fear conditioned (CS-fear) or presented with CSs only (CS-only) then subjected to extinction training and testing. C-Jun was then assayed within neural substrates critical for extinction memory. Inhibited c-Jun levels in the hippocampus (Hipp) and enhanced functional connectivity between the ventromedial prefrontal cortex (vmPFC) and basolateral amygdala (BLA) during extinction training was disrupted by SPS in the CS-fear group only. As a result, these effects were specific to emotional learning/memory. SPS also disrupted inhibited Hipp c-Jun levels, enhanced BLA c-Jun levels, and altered functional connectivity among the vmPFC, BLA, and Hipp during extinction testing in SPS rats in the CS-fear and CS-only groups. As a result, these effects were not specific to emotional learning/memory. Our findings suggest that SPS disrupts neural activity specific to extinction memory, but may also disrupt the retention of fear extinction by mechanisms that do not involve emotional learning/memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.