ArticleNeuroscience2019
Interferon-alpha-Induced Changes in NODDI Predispose to the Development of Fatigue.
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.Neuroscience and biobehavioral reviews · 2026Review
- Sex-specific immune-brain coupling in hippocampal circuits and Alzheimer's disease vulnerability.Research square · 2026Article
- Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson's disease.Brain communications · 2025Article
- Sleep quality and the integrity of ascending reticular activating system - A multimodal MRI study.Heliyon · 2024Article
- Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue.Nature communications · 2024Article
- Effects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters.Psychopharmacology · 2023Article
- High-frequency longitudinal white matter diffusion- and myelin-based MRI database: Reliability and variability.Human brain mapping · 2023Article
- Potential Mechanism of Fatigue Induction and Its Management by JAK Inhibitors in Inflammatory Rheumatic Diseases.Journal of inflammation research · 2023Review
- Increased Inflammation and Treatment of Depression: From Resistance to Reuse, Repurposing, and Redesign.Advances in neurobiology · 2023Article
- Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder.Frontiers in neuroscience · 2022Review
- Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications.Current topics in behavioral neurosciences · 2022Review
- Comparing multiband and singleband EPI in NODDI at 3 T: what are the implications for reproducibility and study sample sizes?Magma (New York, N.Y.) · 2021Article
- Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression.Molecular psychiatry · 2021Review
- What can neuroimmunology teach us about the symptoms of long-COVID?Oxford open immunology · 2021Article
- Fatigue in inflammatory rheumatic disorders: pathophysiological mechanisms.Rheumatology (Oxford, England) · 2019Article
- Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter.Scientific reports · 2019Article
- Detecting Microglial Density With Quantitative Multi-Compartment Diffusion MRI.Frontiers in neuroscience · 2019Article
- Interoception and Inflammation in Psychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Evaluation of fatigue in patients with pancreatic cancer receiving chemotherapy treatment: a cross-sectional observational study.Acta bio-medica : Atenei Parmensis · 2018Observational
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Interferon-alpha (IFN-α) is an important mediator of antiviral immune responses. It is also used clinically in the treatment of hepatitis-C infection. Though effective, IFN-α-based therapies can often impair mood, motivation and cognition, which when severe can appear indistinguishable from major depression. In susceptible patients, fatigue and motivational impairment emerge early and have been linked to changes in basal ganglia (striatal) metabolism, neurochemistry and microstructural integrity. Here we use neurite orientation dispersion and density imaging (NODDI) modeling of multi-shell diffusion MRI to investigate whether changes in orientation-dispersion index (ODI) or neurite density index (NDI) can predict the later emergence of IFN-α-induced fatigue. Eighteen patients initiating IFN-α-based treatment for hepatitis-C underwent diffusion MRI and blood sampling at baseline and 4 h after their first IFN-α injection. They were then followed up with regular psychological assessments for 12 weeks of treatment. IFN-α injection stimulated an acute inflammatory cytokine response and evoked acute fatigue that peaked between 4 and 12 weeks of treatment. Within the brain, IFN-α induced an acute increase in NDI in patients that experienced a simultaneous increase in IFN-α-induced fatigue but not in patients that did not. Acute changes in striatal microstructure additionally predicted the continued development of fatigue but not mood symptoms 4 and 8 weeks later into treatment. Our findings highlight the value of NODDI as a potential in vivo biomarker of the central effects of peripheral inflammation. We highlight the exquisite sensitivity of the striatum to IFN-α and further implicate striatal perturbation in IFN-α-induced fatigue.
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Registered trials
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