ArticleBiology of sex differences2018
Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study.
Article in Biology of sex differences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A comparative systematic review and meta-analysis on the diagnostic accuracy of non-invasive tests forFrontiers in medicine · 2023Pooled it
- Comparative Analysis of Diagnostic Techniques for Helicobacter pylori Infection: Insights for Effective Therapy.Journal of cellular and molecular medicine · 2025Article
- Focusing onFrontiers in cellular and infection microbiology · 2023Review
- A rapid and high-throughput multiplex genetic detection assay for detection, semi-quantification and virulence genotyping ofFrontiers in cellular and infection microbiology · 2023Article
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- Extra-Gastroduodenal Manifestation andArchives of Razi Institute · 2022Article
- Rapid and Sensitive Assay ofFrontiers in microbiology · 2022Article
- What Is New inJournal of clinical medicine · 2021Review
- Induced volatolomics of pathologies.Nature reviews. Chemistry · 2021Review
- Review
- Impact of a Fermented High-Fiber Rye Diet onFrontiers in nutrition · 2020Article
- Optimization ofJournal of clinical laboratory analysis · 2019Article
- Decreasing mortality and hospitalizations with rising costs related to gastric cancer in the USA: an epidemiological perspective.Journal of hematology & oncology · 2018Article
- Correlation between QuantitativeGastroenterology research and practice · 2018Article
- Helicobacter pylori and hypertension-a cross-sectional study based on a healthy population.Science progressArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori causes peptic ulcer disease and gastric cancer only in a subset of infected persons. Sex differences were shown in results of urea breath test (UBT), a commonly used test for the diagnosis of H. pylori infection. However, factors that might explain these differences, or affect UBT values, are not fully understood. We examined differences in UBT values between H. pylori-infected men and women while adjusting for background characteristics such as age, body mass index (BMI), and smoking.
methodsA cross-sectional study was undertaken using coded data from the computerized database of Maccabi Health Services in Israel. Included were adults examined for UBT during 2002-2012 and were found H. pylori positive (UBT > 3.5‰). Multivariable linear mixed models were performed to assess the relationship between sex and UBT quantitative results, while adjusting for background characteristics.
resultsA total of 76,403 patients were included (52% of examined patients during the study period). Adjusted mean UBT value was significantly higher in women 33.8‰ (95% CI 33.4, 34.1) than in men 24.9‰ (95% CI 24.5, 25.3). A significant (P < 0.001) interaction was found between sex and smoking, showing diminished sex-differences in UBT results in smokers. Adjusted mean UBT values increased significantly with age and decreased with BMI, and it was higher in people who lived in low vs high socioeconomic status communities and lower in smokers vs non-smokers.
conclusionsSystemic differences exist between men and women in quantitative UBT results. Host-related and environmental factors might affect UBT quantitative results. These findings have clinical implications regarding confirmation of the success of H. pylori eradication after treatment in various subgroups.
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