Evidence map›Paper›PMID 29291743›Full record

ArticleBreast cancer research : BCR2018

SNPs related to vitamin D and breast cancer risk: a case-control study.

Linnea Huss, Salma Tunå Butt, Peter Almgren, Signe Borgquist, Jasmine Brandt, Asta Försti, Olle Melander, Jonas Manjer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Linnea HussDepartment of Surgery, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden. linnea.huss@med.lu.se.ORCID 0000-0002-8597-9224
Salma Tunå ButtDepartment of Surgery, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
Peter AlmgrenDepartment of Clinical Sciences, Malmö Clinical Research Centre, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
Signe BorgquistDivision of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Jasmine BrandtDepartment of Surgery, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
Asta FörstiDivision of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
Olle MelanderDepartment of Clinical Sciences, Malmö Clinical Research Centre, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
Jonas ManjerDepartment of Surgery, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden.
Lund University · SEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relation to subsequent breast cancer risk. A first step included verification of these SNPs as determinants of vitamin D levels.

methodsThe Malmö Diet and Cancer Study included 17,035 women in a prospective cohort. Genotyping was performed and was successful in 4058 nonrelated women from this cohort in which 865 were diagnosed with breast cancer. Levels of vitamin D (25-hydroxyvitamin D) were available for 700 of the breast cancer cases and 643 of unaffected control subjects. SNPs previously associated with vitamin D in GWASs were identified. Logistic regression analyses yielding ORs with 95% CIs were performed to investigate selected SNPs in relation to low levels of vitamin D (below median) as well as to the risk of breast cancer.

resultsThe majority of SNPs previously associated with levels of vitamin D showed a statistically significant association with circulating vitamin D levels. Heterozygotes of one SNP (rs12239582) were found to have a statistically significant association with a low risk of breast cancer (OR 0.82, 95% CI 0.68-0.99), and minor homozygotes of the same SNP were found to have a tendency towards a low risk of being in the group with low vitamin D levels (OR 0.72, 95% CI 0.52-1.00). Results from stratified analyses showed diverse associations with breast cancer risk for a few of the tested SNPs, depending on whether vitamin D level was high or low.

conclusionsSNPs associated with vitamin D may also be associated with the risk of breast cancer. Even if such a risk is small, the allele frequency of the SNP variants is high, and therefore the population attributable risk could be substantial. It is also possible that vitamin D levels may interact with genomic traits with regard to breast cancer risk.

Indexed as

Genetic Predisposition to DiseaseAdultAgedBreast NeoplasmsCohort StudiesFemaleGene FrequencyGenome-Wide Association StudyGenotypeHumansMiddle AgedPolymorphism, Single NucleotideRisk FactorsVitamin DVitamin DBreast cancerPolymorphismSNPVitamin D

Identifiers

PMID29291743
PMCPMC5748964
OpenAlexW2782082610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.