Evidence map›Paper›PMID 29291683›Full record

ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2018

Impact of the ovarian cycle and pregnancy on plasma chemistry values in ewes.

Micaela E Zywicki, Sharon E Blohowiak, Ronald R Magness, Jeffrey L Segar, Pamela J Kling

Open access · bronzeAbstract read
In one paragraph

Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Micaela E ZywickiDepartment of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI (Zywicki, Blohowiak, Kling).
Sharon E BlohowiakDepartment of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI (Zywicki, Blohowiak, Kling).ORCID http://orcid.org/0000-0002-0779-1269
Ronald R MagnessDepartment of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI (Zywicki, Blohowiak, Kling).
Jeffrey L SegarDepartment of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI (Zywicki, Blohowiak, Kling).
Pamela J KlingDepartment of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI (Zywicki, Blohowiak, Kling).
University of Wisconsin–Madison · US

Funding

Unified Cellular and Molecular CoreP01HD038843 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2001 to 2017
$14.4M
Endocrinology-Reproductive Physiology Training GrantT32HD041921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2004 to 2022
$3.0M
Pregnancy/NO Induced Changes in UAE Ca2+ SignalingR01HL079020 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2007 to 2014
$2.7M
Physiologic Cardiovascular & Uterine eNOS Responses:Role of Endogenous EstrogenR01HL087144 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MAGNESS, RONALD R · 2007 to 2010
$1.8M
Endothelial Function in a Model of IUGR Induced by Uterine Space RestrictionR01HL117341 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MAGNESS, RONALD R · 2014 to 2017
$1.8M
NHLBI NIH HHS R01 HL079020NHLBI NIH HHS R01 HL087144NHLBI NIH HHS R01 HL117341NICHD NIH HHS P01 HD038843NICHD NIH HHS T32 HD041921
6 · The paper itself

Abstract

Normative data for plasma chemistry values in pregnant and non-pregnant reproductive age ewes are scant. Availability of data would aid monitoring of ewe health for both research and veterinary medicine. We determined specific plasma chemistry 95% confidence reference intervals (RIs) in non-pregnant and pregnant ewes. Mixed Western-breed ewes were grouped based on phase of ovarian cycle: luteal ( n = 15), follicular ( n = 17), or late-gestation pregnant ( n = 102). Plasma samples were collected for analysis on a commercial biochemical analyzer. For RIs, chemistry panels for the 3 groups of ewes included nutrients and metabolites (glucose, triglycerides, cholesterol, urea, creatinine, total protein, albumin, and bilirubin), enzymes (lactate dehydrogenase, aspartate transaminase, gamma-glutamyl transferase, alanine aminotransferase, and alkaline phosphatase [ALP]), and micronutrients (calcium, phosphorus, iron, sodium, potassium, and chloride). Sample chemistry values for glucose and total protein in pregnant ewes were lower than in follicular ewes; cholesterol was lower in pregnant and luteal ewes than in follicular ewes. In addition, total bilirubin in pregnant ewes differed from that in luteal ewes, and that in follicular ewes also differed from luteal ewes. ALP in pregnant ewes was higher than other groups; phosphorus in pregnant ewes was lower than in luteal ewes. Iron was higher in pregnant ewes than in luteal ewes, with iron in luteal ewes lower than in follicular ewes. These data provide clinical RIs comparing pregnant and non-pregnant ewes for use in monitoring ewe health in both human research and veterinary medicine.

Indexed as

Alanine TransaminaseAlbuminsAnimalsBilirubinBlood Chemical AnalysisBlood GlucoseCholesterolEstrous CycleFemaleMicronutrientsPregnancyPregnancy, AnimalReference ValuesSheepTriglyceridesAlanine TransaminaseAlbuminsBilirubinBlood GlucoseCholesterolMicronutrientsTriglyceridesBiochemistrymicronutrientsreproductionsheep

Identifiers

PMID29291683
PMCPMC5810928
OpenAlexW2782451939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.