ArticleJournal of neurogastroenterology and motility2018
Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus.
Article in Journal of neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Combined anti-inflammatory and laxative effect of mango kernels-based effervescent suppositories loaded with (multi)metallic nanoparticles synthesized using ash of plantain peels and gel of Aloe vera.Drug delivery and translational research · 2026Article
- Impact of PAR2 on Tight Junctions and Esophageal Mucosal Inflammation in Rats with Gastroesophageal Reflux Disease.Neurogastroenterology and motility · 2026Article
- THE DOUBLE BURDEN OF CIRRHOSIS AND ACUTE PANCREATITIS: AMPLIFIED RISKS FOR NUTRITIONAL AND GASTROINTESTINAL COMPLICATIONS.Arquivos de gastroenterologia · 2026Article
- Effect of Probiotics on Improving Intestinal Mucosal Permeability and Inflammation after Surgery.Gut and liver · 2025Article
- Neuro-inflammatory response dynamics following intestinal surgery: a mini-review.Frontiers in medicine · 2025Review
- The Effect of CKD-495, Eupacidin, and Their Marker Compounds on Altered Permeability in a Postoperative Ileus Animal Model.Medicina (Kaunas, Lithuania) · 2024Article
- A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility.BMC biotechnology · 2023Article
- Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options.Journal of neurogastroenterology and motility · 2022Review
- Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model.Journal of neurogastroenterology and motility · 2021Article
- Intestinal Barrier, Claudins and Mycotoxins.Toxins · 2021Review
- Ileus in Acute Pancreatitis Correlates with Severity of Pancreatitis, Not Volume of Fluid Resuscitation or Opioid Use: Observations from Mid-West Cohort.Internal and emergency medicine · 2021Article
- Present and Future Therapeutic Approaches to Barrier Dysfunction.Frontiers in nutrition · 2021Review
- Early oral nutrition improves postoperative ileus through the TRPA1/CCK1-R-mediated mast cell-nerve axis.Annals of translational medicine · 2020Article
- Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model.Gut and liver · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsPostoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are lacking. We aim to correlate the recovery time of postoperative dysmotility with that of inflammation and mucosal permeability.
methodsAn experimental POI model of guinea pig was used. Contractile activity of the circular muscle of the stomach, jejunum, ileum, and proximal colon was measured through a tissue bath study. Inflammatory cells were counted, and the expression of calprotectin and tryptase were analyzed. The expression of protease-activated receptor 2 (PAR-2), claudin-1, and claudin-2 were analyzed with immunofluorescence.
resultsThe small bowel and colon showed decreased contractile amplitude in the POI groups compared to control. In contrast to the colon, the contractile amplitude of the small bowel significantly recovered in the POI group at 6 hours after the operation compared to the control group. Inflammation was highly significant in the POI groups compared to the control and sham groups, especially in the colon. Immunofluorescence showed increased PAR-2 expression in the POI groups compared to sham. The decreased claudin-1 expression and increased claudin-2 expression may suggest increased mucosal permeability of the small bowel and colon in the POI groups.
conclusionsIncreased inflammation and mucosal permeability may play an important role in the differential recovery stages in POI. These data may provide further insights into the pathophysiology and potential new therapeutic prospects of POI.
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Registered trials
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